The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Pediatr Obes. 2022 Oct;17(10):e12926. doi: 10.1111/ijpo.12926. Epub 2022 May 4.
Body mass index is associated with carotid intima-media thickness and distensibility in adults and children.
To examine whether general and specific fat depots are associated with these markers of arterial health at school age.
This cross-sectional analysis was embedded in a population-based prospective cohort study among 4708 children aged 10 years. Body, lean and fat mass index were estimated by dual-energy X-ray absorptiometry. Pericardial, visceral and liver fat were estimated by magnetic resonance imaging. Carotid intima-media thickness and distensibility were measured by ultrasound.
A 1-standard-deviation-score (SDS) higher body mass index was associated with higher carotid intima-media thickness (0.06 SDS, 95% confidence interval [CI]: 0.03-0.08) and lower distensibility (-0.17 SDS, 95% CI: -0.20 to -0.14). These associations tended to be similar for lean mass index. A 1-SDS higher fat mass index was associated with lower carotid intima-media thickness (-0.08 SDS, 95% CI: -0.11 to -0.05) and lower distensibility (-0.10 SDS, 95% CI: -0.14 to -0.07). A 1-SDS higher liver fat fraction was associated with lower carotid intima-media thickness (-0.04 SDS, 95% CI: -0.08 to -0.00) and lower distensibility (-0.06 SDS, 95% CI: -0.10 to -0.03). We observed similar associations for visceral fat.
At school age, lean and fat mass seem to be differentially related to carotid intima-media thickness but not distensibility. Arterial development might be affected by lean mass, general and specific fat mass.
体重指数与成人和儿童的颈动脉内膜-中层厚度和可扩张性有关。
研究在学龄儿童中，一般和特定脂肪组织与这些动脉健康标志物的相关性。
这是一项横断面分析，嵌入了一项基于人群的前瞻性队列研究，共纳入了 4708 名 10 岁儿童。通过双能 X 射线吸收法估计身体、瘦体重和脂肪质量指数。通过磁共振成像估计心包、内脏和肝脏脂肪。通过超声测量颈动脉内膜-中层厚度和可扩张性。
体重指数每增加一个标准差（SDS），颈动脉内膜-中层厚度增加 0.06 SDS（95%置信区间：0.03-0.08），可扩张性降低 0.17 SDS（95%置信区间：0.20-0.14）。这些关联在瘦体重指数方面也趋于相似。脂肪质量指数每增加一个 SDS，颈动脉内膜-中层厚度降低 0.08 SDS（95%置信区间：0.11-0.05），可扩张性降低 0.10 SDS（95%置信区间：0.14-0.07）。肝脂肪分数每增加一个 SDS，颈动脉内膜-中层厚度降低 0.04 SDS（95%置信区间：0.08-0.00），可扩张性降低 0.06 SDS（95%置信区间：0.10-0.03）。我们观察到内脏脂肪也存在类似的关联。
在学龄期，瘦体重和脂肪量似乎与颈动脉内膜-中层厚度有关，但与可扩张性无关。动脉发育可能受到瘦体重、一般和特定脂肪量的影响。
