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Curr Atheroscler Rep. 2023 Jun;25(6):275-298. doi: 10.1007/s11883-023-01101-6. Epub 2023 May 6.
Non-invasive measurements such as arterial stiffness serve as proxy surrogates for detection of early atherosclerosis and ASCVD risk stratification. These surrogate measurements are influenced by age, gender, and ethnicity and affected by the physiological changes of puberty and somatic growth in children and adolescents.
There is no consensus of the ideal method to measure surrogate markers in youth (< 18 years of age), nor standardized imaging protocols for youth. Currently, pediatric normative data are available but not generalizable. In this review, we provide rationale on how currently used surrogates can help identify subclinical atherosclerosis in youth and affirm their role in identifying youth at risk for premature CVD.
动脉僵硬度等非侵入性测量可作为早期动脉粥样硬化和 ASCVD 风险分层的替代指标。这些替代指标受年龄、性别和种族的影响，并受儿童和青少年青春期和躯体生长的生理变化的影响。
目前尚无理想的方法来测量青年（<18 岁）的替代标志物，也没有针对青年的标准化成像方案。目前，已有儿科正常数据，但不具有普遍性。在这篇综述中，我们提供了使用目前使用的替代指标如何帮助识别青少年亚临床动脉粥样硬化的基本原理，并肯定了它们在识别有过早发生 CVD 风险的青少年方面的作用。
