Samos Andres, McGaughey Vanessa, Rieger Sandra, Lisse Thomas S
University of Miami, Biology Department, 1301 Memorial Drive, Cox Science Center, Coral Gables, FL, USA.
Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA.
Regen Ther. 2022 Apr 19;20:78-85. doi: 10.1016/j.reth.2022.03.008. eCollection 2022 Jun.
The ability of an animal to regenerate lost tissue and body parts has obviously life-saving implications. Understanding how this ability became restricted or active in specific animal lineages will help us understand our own regeneration. According to phylogenic analysis, the glial cell line-derived neurotrophic factor (GDNF) signaling pathway, but not other family members, is conserved in axolotls, a salamander with remarkable regenerative capacity. Furthermore, comparing the pro-regenerative Spiny mouse to its less regenerative descendant, the House mouse, revealed that the GDNF signaling pathway, but not other family members, was induced in regenerating Spiny mice. According to GDNF receptor expression analysis, GDNF may promote hair follicle neogenesis - an important feature of skin regeneration - by determining the fate of dermal fibroblasts as part of new hair follicles. These findings support the idea that GDNF treatment will promote skin regeneration in humans by demonstrating the GDNF signaling pathway's ancestral and cellular nature.
动物再生受损组织和身体部位的能力显然具有挽救生命的意义。了解这种能力在特定动物谱系中是如何受到限制或保持活跃，将有助于我们理解人类自身的再生机制。根据系统发育分析，胶质细胞源性神经营养因子（GDNF）信号通路，而非其他家族成员，在蝾螈（一种具有显著再生能力的蝾螈）中是保守的。此外，将具有促进再生能力的刺毛鼠与其再生能力较弱的后代家鼠进行比较，发现GDNF信号通路，而非其他家族成员，在再生的刺毛鼠中被诱导。根据GDNF受体表达分析，GDNF可能通过决定作为新毛囊一部分的真皮成纤维细胞的命运来促进毛囊新生——皮肤再生的一个重要特征。这些发现通过证明GDNF信号通路的祖先性和细胞特性，支持了GDNF治疗将促进人类皮肤再生的观点。
