Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, Republic of Korea.
Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of Korea.
Biomed Res Int. 2022 Apr 25;2022:3206594. doi: 10.1155/2022/3206594. eCollection 2022.
The prevalence of neurodegenerative dementia is increasing owing to the rapid growth of the older population. We investigated risks and causes of mortality in Korean patients with neurodegenerative dementia using data from the Korean Health Insurance Review and Assessment Service-National Sample Cohort with the aim to improve their care. From a pool of 1,125,691 patients, 11,215 patients aged ≥60 years who were diagnosed with dementia between 2002 and 2013 were examined along with 44,860 matched controls. A Cox proportional hazard model was used to calculate crude and adjusted hazard ratios (HRs). During the follow-up period, 34.5% and 18.8% of individuals in the neurodegenerative dementia and control groups, respectively, died ( < 0.001). The adjusted HR for mortality in the neurodegenerative dementia group was 2.11 (2.41 and 1.96 in men and women, respectively). Moreover, the adjusted HRs in patients with neurodegenerative dementia were 3.25, 2.77, and 1.84 for those diagnosed at ages 60-69, 70-79, and ≥80 years, respectively. The highest odds ratio for mortality was noted among patients with neurologic disease (15.93) followed by those with mental disease (4.89). These data show that the risk of mortality increased regardless of age and sex in Korean patients with neurodegenerative dementia.
由于老年人口的快速增长，神经退行性痴呆的患病率正在上升。我们使用韩国健康保险审查和评估服务-全国样本队列的数据，对韩国神经退行性痴呆患者的死亡风险和原因进行了调查，旨在改善他们的护理。在一个 1125691 名患者的样本池中，我们检查了 2002 年至 2013 年间被诊断患有痴呆症的 11215 名年龄≥60 岁的患者，以及 44860 名匹配的对照组患者。使用 Cox 比例风险模型计算了粗死亡率和调整后的危险比（HR）。在随访期间，神经退行性痴呆组和对照组分别有 34.5%和 18.8%的个体死亡（<0.001）。神经退行性痴呆组的死亡率调整 HR 为 2.11（男性为 2.41，女性为 1.96）。此外，在神经退行性痴呆患者中，分别在 60-69 岁、70-79 岁和≥80 岁诊断的患者的调整 HR 分别为 3.25、2.77 和 1.84。死亡率的最高比值比见于患有神经系统疾病的患者（15.93），其次是患有精神疾病的患者（4.89）。这些数据表明，韩国神经退行性痴呆患者的死亡率无论年龄和性别均呈上升趋势。
