Eleje George Uchenna, Onubogu Chinyere Ukamaka, Fiebai Preye Owen, Mbachu Ikechukwu Innocent, Akaba Godwin Otuodichinma, Loto Olabisi Morebise, Usman Hadiza Abdullahi, Rabiu Ayyuba, Chibuzor Moriam Taiwo, Chukwuanukwu Rebecca Chinyelu, Joe-Ikechebelu Ngozi Nneka, Nwankwo Chike Henry, Kalu Stephen Okoroafor, Ogbuagu Chukwuanugo Nkemakonam, Chukwurah Shirley Nneka, Uzochukwu Chinwe Elizabeth, Oppah Ijeoma Chioma, Ahmed Aishat, Egeonu Richard Obinwanne, Jibuaku Chiamaka Henrietta, Inuyomi Samuel Oluwagbenga, Adesoji Bukola Abimbola, Anyang Ubong Inyang, Ogwaluonye Uchenna Chukwunonso, Emeka Ekene Agatha, Igue Odion Emmanuel, Okoro Ogbonna Dennis, Aja Prince Ogbonnia, Chidozie Chiamaka Perpetua, Ibrahim Hadiza Sani, Aliyu Fatima Ele, Numan Aisha Ismaila, Omoruyi Solace Amechi, Umeononihu Osita Samuel, Okoro Chukwuemeka Chukwubuikem, Nwaeju Ifeanyi Kingsley, Onwuegbuna Arinze Anthony, Umeh Eric Okechukwu, Nweje Sussan Ifeyinwa, Eleje Lydia Ijeoma, Ajuba Ifeoma Clara, Ikwuka David Chibuike, Igbodike Emeka Philip, Chigbo Chisom God'swill, Ebubedike Uzoamaka Rufina, Okafor Chigozie Geoffrey, Obiegbu Nnaedozie Paul, Yakasai Ibrahim Adamu, Ezechi Oliver Chukwujekwu, Ikechebelu Joseph Ifeanyichukwu
Effective Care Research Unit, Department of Obstetrics and Gynecology, Nnamdi Azikiwe University, Awka, Nigeria.
Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nnewi, Nigeria.
SAGE Open Med. 2022 Apr 28;10:20503121221095411. doi: 10.1177/20503121221095411. eCollection 2022.
To systematically review literature and identify mother-to-child transmission rates of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus among pregnant women with single, dual, or triplex infections of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus in Nigeria. PRISMA guidelines were employed. Searches were on 19 February 2021 in PubMed, Google Scholar and CINAHL on studies published from 1 February 2001 to 31 January 2021 using keywords: "MTCT," "dual infection," "triplex infection," "HIV," "HBV," and "HCV." Studies that reported mother-to-child transmission rate of at least any of human immunodeficiency virus, hepatitis B virus and hepatitis C virus among pregnant women and their infant pairs with single, dual, or triplex infections of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus in Nigeria irrespective of publication status or language were eligible. Data were extracted independently by two authors with disagreements resolved by a third author. Meta-analysis was performed using the random effects model of DerSimonian and Laird, to produce summary mother-to-child transmission rates in terms of percentage with 95% confidence interval. Protocol was prospectively registered in PROSPERO: CRD42020202070. The search identified 849 reports. After screening titles and abstracts, 25 full-text articles were assessed for eligibility and 18 were included for meta-analysis. We identified one ongoing study. Pooled mother-to-child transmission rates were 2.74% (95% confidence interval: 2.48%-2.99%; 5863 participants; 15 studies) and 55.49% (95% confidence interval: 35.93%-75.04%; 433 participants; three studies), among mother-infant pairs with mono-infection of human immunodeficiency virus and hepatitis B virus, respectively, according to meta-analysis. Overall, the studies showed a moderate risk of bias. The pooled rate of mother-to-child transmission of human immunodeficiency virus was 2.74% and hepatitis B virus was 55.49% among mother-infant pairs with mono-infection of HIV and hepatitis B virus, respectively. No data exists on rates of mother-to-child transmission of hepatitis C virus on mono-infection or mother-to-child transmission of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus among mother-infant pairs with dual or triplex infection of HIV, hepatitis B virus and HCV in Nigeria.
系统回顾文献，确定尼日利亚感染人类免疫缺陷病毒（HIV）、乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）的单重、双重或三重感染孕妇中HIV、HBV和HCV的母婴传播率。采用PRISMA指南。于2021年2月19日在PubMed、谷歌学术和CINAHL中检索2001年2月1日至2021年1月31日发表的研究，使用关键词：“母婴传播”、“双重感染”、“三重感染”、“HIV”、“HBV”和“HCV”。纳入报告了尼日利亚感染HIV、HBV和HCV的单重、双重或三重感染孕妇及其婴儿对中至少任何一种HIV、HBV和HCV母婴传播率的研究，无论其发表状态或语言如何。由两名作者独立提取数据，分歧由第三名作者解决。使用DerSimonian和Laird随机效应模型进行荟萃分析，以得出百分比形式的汇总母婴传播率及95%置信区间。该方案已在PROSPERO中进行前瞻性注册：CRD42020202070。检索共识别出849篇报告。在筛选标题和摘要后，评估了25篇全文文章的 eligibility，18篇纳入荟萃分析。我们识别出一项正在进行的研究。根据荟萃分析，HIV单重感染母婴对的汇总母婴传播率为2.74%（95%置信区间：2.48%-2.99%；5863名参与者；15项研究），HBV单重感染母婴对的汇总母婴传播率为55.49%（95%置信区间：35.93%-75.04%；433名参与者；3项研究）。总体而言，这些研究显示出中度偏倚风险。HIV单重感染母婴对中HIV的汇总母婴传播率为2.74%，HBV为55.49%。尼日利亚不存在关于HCV单重感染母婴传播率或HIV、HBV和HCV双重或三重感染母婴对中HIV、HBV和HCV母婴传播率的数据。 （注：原文中“eligibility”未准确翻译，可根据语境理解为“符合纳入标准情况”等类似含义）
