Jaswal Amita, Sharma Samta, Uthra Chhavi, Yadav Deepa, Shrivastava Sadhana, Shukla Sangeeta
Reproductive Biology and Toxicology Laboratory, UNESCO-Trace Element Satellite Centre, School of Studies in Zoology, Jiwaji University.
Toxicol Res (Camb). 2022 Apr 4;11(2):367-373. doi: 10.1093/toxres/tfac014. eCollection 2022 Apr.
Drug-induced nephrotoxicity is a common problem in clinical medicine and the frequency of drug-related acute and chronic kidney dysfunction worldwide. One of them is anti-tuberculosis (TB) drugs that cause renal function impairment during TB treatment. Medicinal plants contain bioactive compounds that are capable for treating drug or toxin-induced renal disorders. The aim of the present study was to assess the protective effect of the ethanolic extract of seeds (NS) against anti-TB drugs (ATDs) induced nephrotoxicity in Wistar albino rats. Rats were treated with ATDs for 12weeks (3 alternative days in a week). Supplementation with 125mg NS/kg, p.o. was administered to the experimental rats for 12weeks (3 alternative days in a week considering next day of ATDs treatment). The results demonstrated that NS treatment protected against renal damage induced by ATDs, as evidenced by the reduction in serum urea, creatinine, uric acid, urea nitrogen levels, pro-inflammatory markers (TNF-α and IL-6), whereas improvement in histological tubular and glomerular damage. In addition, NS enhanced the antioxidant enzyme activity (superoxide dismutase and catalase) and decreased the lipid peroxidation and glutathione level in the kidney. In conclusion, NS could reduce chronic nephritis in ATDs treated group through suppressing inflammation and oxidative stress. It suggests that NS can be used as supplementary preventive and protective drug against kidney injury during anti-TB treatment.
药物性肾毒性是临床医学中常见的问题，也是全球范围内与药物相关的急慢性肾功能障碍的常见病因。其中之一是抗结核药物，在结核病治疗期间会导致肾功能损害。药用植物含有能够治疗药物或毒素引起的肾脏疾病的生物活性化合物。本研究的目的是评估种子乙醇提取物（NS）对Wistar白化大鼠抗结核药物（ATD）诱导的肾毒性的保护作用。大鼠接受ATD治疗12周（每周3天交替给药）。给实验大鼠口服补充125mg NS/kg，持续12周（考虑到ATD治疗的次日，每周3天交替给药）。结果表明，NS治疗可预防ATD诱导的肾损伤，血清尿素、肌酐、尿酸、尿素氮水平、促炎标志物（TNF-α和IL-6）降低，组织学上肾小管和肾小球损伤改善，均证明了这一点。此外，NS增强了抗氧化酶活性（超氧化物歧化酶和过氧化氢酶），并降低了肾脏中的脂质过氧化和谷胱甘肽水平。总之，NS可通过抑制炎症和氧化应激来减轻ATD治疗组的慢性肾炎。这表明NS可作为抗结核治疗期间预防和保护肾脏损伤的辅助药物。
