College of Animal Science and Technology, Guangxi University, Nanning, PR China.
Int J Biol Macromol. 2011 Nov 1;49(4):801-5. doi: 10.1016/j.ijbiomac.2011.07.017. Epub 2011 Jul 28.
The aim of the present study was to investigate the immunomodulatory effect and antioxidant activity of carboxymethylpachymaran on cyclophosphamide-induced immunosuppression in mice in vivo. The results showed that carboxymethylpachymaran could be used to overcome the cyclophosphamide-induced immunosuppression in mice. Moreover, it significantly increased the thymus and spleen indices, lysozyme, catalase and superoxidase dismutase activities, and total antioxidant capacity. In contrast, it decreased xanthine oxidase activity and malondialdehyde levels. The results indicated that carboxymethylpachymaran might play an important role in the prevention of oxidative damage in the immunological system.
本研究旨在探讨羧甲基茯苓多糖对环磷酰胺诱导的免疫抑制小鼠的免疫调节作用和抗氧化活性。结果表明，羧甲基茯苓多糖可用于克服环磷酰胺诱导的小鼠免疫抑制。此外，它还显著提高了胸腺和脾脏指数、溶菌酶、过氧化氢酶和超氧化物歧化酶的活性以及总抗氧化能力。相反，它降低了黄嘌呤氧化酶的活性和丙二醛的水平。结果表明，羧甲基茯苓多糖可能在预防免疫系统氧化损伤中发挥重要作用。
