Sinagra Zachary P, Davis Joshua S, Lorimer Michelle, de Steiger Richard N, Graves Stephen E, Yates Piers, Manning Laurens
Department of Orthopaedic Surgery, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.
School of Medicine, University of Western Australia, Perth, Western Australia, Australia.
Bone Jt Open. 2022 May;3(5):367-373. doi: 10.1302/2633-1462.35.BJO-2022-0011.R1.
National joint registries under-report revisions for periprosthetic joint infection (PJI). We aimed to validate PJI reporting to the Australian Orthopaedic Association National Joint Arthroplasty Registry (AOANJRR) and the factors associated with its accuracy. We then applied these data to refine estimates of the total national burden of PJI.
A total of 561 Australian cases of confirmed PJI were captured by a large, prospective observational study, and matched to data available for the same patients through the AOANJRR.
In all, 501 (89.3%) cases of PJI recruited to the prospective observational study were successfully matched with the AOANJRR database. Of these, 376 (75.0%) were captured by the registry, while 125 (25.0%) did not have a revision or reoperation for PJI recorded. In a multivariate logistic regression analysis, early (within 30 days of implantation) PJIs were less likely to be reported (adjusted odds ratio (OR) 0.56; 95% confidence interval (CI) 0.34 to 0.93; p = 0.020), while two-stage revision procedures were more likely to be reported as a PJI to the registry (OR 5.3 (95% CI 2.37 to 14.0); p ≤ 0.001) than debridement and implant retention or other surgical procedures. Based on this data, the true estimate of the incidence of PJI in Australia is up to 3,900 cases per year.
In Australia, infection was not recorded as the indication for revision or reoperation in one-quarter of those with confirmed PJI. This is better than in other registries, but suggests that registry-captured estimates of the total national burden of PJI are underestimated by at least one-third. Inconsistent PJI reporting is multifactorial but could be improved by developing a nested PJI registry embedded within the national arthroplasty registry. Cite this article: 2022;3(5):367-373.
国家联合注册机构对假体周围关节感染(PJI)翻修手术的报告存在漏报情况。我们旨在验证向澳大利亚骨科协会国家关节置换注册机构(AOANJRR)报告的PJI情况及其准确性相关因素。然后应用这些数据来完善对全国PJI总负担的估计。
一项大型前瞻性观察性研究共纳入561例确诊为PJI的澳大利亚病例,并将其与通过AOANJRR获得的相同患者的数据进行匹配。
前瞻性观察性研究纳入的561例PJI病例中,有501例(89.3%)成功与AOANJRR数据库匹配。其中,登记机构记录了376例(75.0%),而125例(25.0%)没有记录PJI的翻修或再次手术情况。在多因素逻辑回归分析中,早期(植入后30天内)PJI被报告的可能性较小(调整优势比(OR)为0.56;95%置信区间(CI)为0.34至0.93;p = 0.020),而与清创和保留植入物或其他手术程序相比,两阶段翻修手术作为PJI向登记机构报告的可能性更大(OR为5.3(95%CI为2.37至14.0);p≤0.001)。基于这些数据,澳大利亚PJI发病率的真实估计高达每年3900例。
在澳大利亚,四分之一确诊为PJI的患者感染未被记录为翻修或再次手术的指征。这比其他注册机构的情况要好,但表明登记机构所记录的全国PJI总负担估计至少被低估了三分之一。PJI报告不一致是多因素造成的,但通过在国家关节置换注册机构内建立一个嵌套式PJI注册机构可能会有所改善。引用本文:2022;3(5):367 - 373。