Kinobe Robert, Wiyatno Ageng, Artika I Made, Safari Dodi
Department of Biochemistry, Faculty of Mathematics and Natural Sciences, Bogor Agricultural University, Bogor, Indonesia.
Eijkman Institute for Molecular Biology, Jakarta, Indonesia.
Rev Med Virol. 2022 Nov;32(6):e2361. doi: 10.1002/rmv.2361. Epub 2022 May 5.
Enterovirus A71 is a major causative pathogen of hand, foot and mouth disease. It has become a global public health threat, and is especially important for infants and young children in the Asian-Pacific countries. The enterovirus A71 is a non-enveloped virus of the Picornaviridae family having a single-stranded positive-sense RNA genome of about 7.4 kb which encodes the structural and nonstructural proteins. Currently there are no US FDA-approved vaccines or antiviral therapy available against enterovirus A71 infection. Although enterovirus A71 vaccines have been licenced in China, clinically approved vaccines for widespread vaccination programs are lacking. Substantial progress has recently been achieved on understanding the structure and function of enterovirus A71 proteins together with information on the viral genetic diversity and geographic distribution. The present review is intended to provide an overview on our current understanding of the molecular biology and epidemiology of enterovirus A71 which will aid the development of vaccines, therapeutics and other control strategies so as to bolster the preparedness for future enterovirus A71 outbreaks.
肠道病毒A71是手足口病的主要致病病原体。它已成为全球公共卫生威胁，对亚太国家的婴幼儿尤为重要。肠道病毒A71是小RNA病毒科的一种无包膜病毒，具有约7.4 kb的单链正义RNA基因组，该基因组编码结构蛋白和非结构蛋白。目前尚无美国食品药品监督管理局批准的针对肠道病毒A71感染的疫苗或抗病毒疗法。尽管肠道病毒A71疫苗已在中国获得许可，但缺乏用于广泛疫苗接种计划的临床批准疫苗。最近在了解肠道病毒A71蛋白的结构和功能以及病毒遗传多样性和地理分布信息方面取得了重大进展。本综述旨在概述我们目前对肠道病毒A71分子生物学和流行病学的理解，这将有助于疫苗、治疗方法和其他控制策略的开发，从而加强对未来肠道病毒A71疫情的防范。
