用于生物样本中片上自旋检测的玻璃可模压缺口型微波结构。

Glass-patternable notch-shaped microwave architecture for on-chip spin detection in biological samples.

机构信息

Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan.

Department of Chemistry, Graduate School of Science, Osaka City University, Osaka 558-8585, Japan.

出版信息

Lab Chip. 2022 Jun 28;22(13):2519-2530. doi: 10.1039/d2lc00112h.

DOI:10.1039/d2lc00112h

PMID:35510631

Abstract

We report a notch-shaped coplanar microwave waveguide antenna on a glass plate designed for on-chip detection of optically detected magnetic resonance (ODMR) of fluorescent nanodiamonds (NDs). A lithographically patterned thin wire at the center of the notch area in the coplanar waveguide realizes a millimeter-scale ODMR detection area (1.5 × 2.0 mm) and gigahertz-broadband characteristics with low reflection (∼8%). The ODMR signal intensity in the detection area is quantitatively predictable by numerical simulation. Using this chip device, we demonstrate a uniform ODMR signal intensity over the detection area for cells, tissue, and worms. The present demonstration of a chip-based microwave architecture will enable scalable chip integration of ODMR-based quantum sensing technology into various bioassay platforms.

摘要

我们报告了一种在玻璃片上的具有切口形状的共面微波波导天线，该天线设计用于芯片上检测荧光纳米金刚石（NDs）的光探测磁共振（ODMR）。共面波导中切口区域中心的光刻图案化细导线实现了毫米级 ODMR 检测区域（1.5×2.0mm）和具有低反射（约 8%）的千兆赫宽带特性。通过数值模拟可以定量预测检测区域中的 ODMR 信号强度。使用这种芯片器件，我们证明了在细胞、组织和蠕虫中检测区域内的 ODMR 信号强度具有均匀性。本研究中基于芯片的微波结构的演示将使基于 ODMR 的量子传感技术的可扩展芯片集成到各种生物分析平台中成为可能。