Lin Xing, Xu Yangyang, Shen Ling, Lin Zongtong, Liu Pingfan, Yang Zhongjie
Department of Otolaryngology，Fuzhou Children's Hospital of Fujian Province，Fuzhou，350000，China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2022 Apr;36(4):269-274. doi: 10.13201/j.issn.2096-7993.2022.04.006.
To explore the value of total IgE in the diagnosis of atopy in children and adolescents. This cross-sectional study analyzed data from the National Health and Nutrition Examination Survey from 2005-2006 included measurement of total and specific IgE levels and allergy questions for 6-19 year old children and adolescents. According to the results of specific IgE, participants were divided into the atopic or non- atopic group. Based on questionnaire, participants were divided into the rhinitis or non-rhinitis group. To compare the difference of total IgE between groups. The relationship between total IgE and atopy was analyzed. The value of total IgE in the diagnosis of atopy was analyzed by ROC curve. ①The geometric mean total IgE level in the non-atopic subjects and the atopic subjects were 24.4 kU/L and 153.1 kU/L, respectively. The difference between the two groups was statistically significant（<0.01）. ②In logistic regression analyses, we observed the adjusted odds ratio（OR） for atopy with a 10-fold increase in total IgE level was 17.6[95%：14.1-22.3], statistically significant changes（<0.01）. ③The area under the receiver operator characteristic curve（AUC） of total IgE for diagnosing atopy in the total population were 0.857. The specificity and sensitivity of total IgE at the optimal cutoff of 54.3 kU/L on the ROC curve for diagnosing atopy were76.4%, and 80.0%, respectively. At the optimal cutoff of 54.6 kU/L for diagnosing atopy in the population with rhinitis, AUC, specificity, and sensitivity were 0.888, 86.7% and 77.0%, respectively. At the optimal cutoff of 59.0 kU/L for diagnosing atopy in the population with non-rhinitis, AUC, specificity, and sensitivity were 0.841, 74.8% and 78.6%, respectively. ④The diagnostic specificity of atopy increased with total IgE, while the sensitivity decreased. There was a close relationship between total IgE and atopy. Total IgE level can be used to discriminates children and adolescents with and without atopy.
探讨总IgE在儿童和青少年特应性疾病诊断中的价值。这项横断面研究分析了2005 - 2006年美国国家健康与营养检查调查的数据，包括对6至19岁儿童和青少年的总IgE和特异性IgE水平的测量以及过敏相关问题。根据特异性IgE的结果，将参与者分为特应性组或非特应性组。基于问卷，将参与者分为鼻炎组或非鼻炎组。比较各组间总IgE的差异。分析总IgE与特应性之间的关系。通过ROC曲线分析总IgE在特应性疾病诊断中的价值。①非特应性受试者和特应性受试者的总IgE几何平均水平分别为24.4 kU/L和153.1 kU/L。两组之间的差异具有统计学意义（<0.01）。②在逻辑回归分析中，我们观察到总IgE水平增加10倍时，特应性的调整优势比（OR）为17.6[95%：14.1 - 22.3]，有统计学意义的变化（<0.01）。③总IgE用于诊断总体人群特应性疾病的受试者工作特征曲线（AUC）下面积为0.857。在ROC曲线上诊断特应性疾病的最佳截断值为54.3 kU/L时，总IgE的特异性和敏感性分别为76.4%和80.0%。在鼻炎人群中诊断特应性疾病的最佳截断值为54.6 kU/L时，AUC、特异性和敏感性分别为0.888、86.7%和77.0%。在非鼻炎人群中诊断特应性疾病的最佳截断值为59.0 kU/L时，AUC、特异性和敏感性分别为0.841、74.8%和78.6%。④特应性疾病的诊断特异性随总IgE升高而增加，而敏感性降低。总IgE与特应性之间存在密切关系。总IgE水平可用于区分有或无特应性的儿童和青少年。
