Department of Allergy, The First Affiliated Hospital of Weifang Medical University/Weifang People's Hospital, Weifang, China.
Department of Central Laboratory, The First Affiliated Hospital of Weifang Medical University/Weifang People's Hospital, Weifang, China.
Mediators Inflamm. 2021 Jun 25;2021:6627087. doi: 10.1155/2021/6627087. eCollection 2021.
Immunoglobulin E (IgE) is the most important promoter of allergic inflammation. However, there are few systematic studies on IgE in age range, genders, disease spectrum, and time regularity.
To screen the common allergens, allergen spectrum, and IgE difference between type 2 inflammatory allergic diseases and other allergic diseases in Weifang, China.
A retrospective study was performed by estimating patients' clinical data suffering from allergic diseases (urticaria, pollinosis, allergic rhinitis, atopic dermatitis, and bronchial asthma) between May 2019 and April 2020 using an allergen detection kit of Macro-Union Pharmaceutical.
732 of the 1367 patients showed different antigen positive, and the positive rate was 53.5%. The most common allergens were dust mites, mixed fungi, Artemisia pollen, cat/dog dander, and cockroaches. There were 27.0% (369/1367) of the patients with single positive allergen-specific IgE (sIgE), 26.5% (363/1367) with multiple-positive IgE. The total immunoglobulin E (tIgE) levels varied with gender, age, and type of disease. There was a difference in the distribution of allergens between children and adults. A positive correlation between the serum-specific IgE and the corresponding local inhaled allergen density was observed.
In this study, we found that type 2 inflammatory allergic diseases have higher serum IgE and a higher probability of inhaled sIgE positive. According to age, gender, and condition, serological IgE detection of allergens provides new insight into the early diagnosis and prevention of allergic diseases.
免疫球蛋白 E（IgE）是过敏炎症最重要的促进剂。然而，关于 IgE 在年龄范围、性别、疾病谱和时间规律方面的系统研究较少。
筛选中国潍坊 2 型炎症性过敏性疾病与其他过敏性疾病的常见过敏原、过敏原谱和 IgE 差异。
采用回顾性研究方法，使用 Macro-Union 制药的过敏原检测试剂盒，估算 2019 年 5 月至 2020 年 4 月间患有过敏性疾病（荨麻疹、花粉症、过敏性鼻炎、特应性皮炎和支气管哮喘）的患者的临床数据。
1367 例患者中有 732 例显示出不同的抗原阳性，阳性率为 53.5%。最常见的过敏原是尘螨、混合真菌、蒿属花粉、猫/狗皮屑和蟑螂。27.0%（369/1367）的患者存在单一阳性过敏原特异性 IgE（sIgE），26.5%（363/1367）的患者存在多种阳性 IgE。总免疫球蛋白 E（tIgE）水平随性别、年龄和疾病类型而变化。儿童和成人的过敏原分布存在差异。血清特异性 IgE 与相应局部吸入性过敏原密度之间存在正相关。
在这项研究中，我们发现 2 型炎症性过敏性疾病的血清 IgE 水平更高，吸入性 sIgE 阳性的可能性更高。根据年龄、性别和病情，对过敏原进行血清 IgE 检测为过敏性疾病的早期诊断和预防提供了新的视角。
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