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β adrenergic signaling regulates hematopoietic stem and progenitor cell commitment and therapy sensitivity in multiple myeloma.

作者信息

Nair Remya, Subramaniam Vimal, Barwick Benjamin G, Gupta Vikas A, Matulis Shannon M, Lonial Sagar, Boise Lawrence H, Nooka Ajay K, Muthumalaiappan Kuzhali, Shanmugam Mala

机构信息

Department of Hematology and Medical Oncology, Winship Cancer Institute, School of Medicine, Emory University, Atlanta, GA.

Department of Surgery, Loyola University Medical Center, Maywood, Illinois, USA; Burn and Shock Trauma Research Institute, Loyola University Chicago, Chicago, Illinois.

出版信息

Haematologica. 2022 Sep 1;107(9):2226-2231. doi: 10.3324/haematol.2022.280907.

DOI:10.3324/haematol.2022.280907
PMID:35511673
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9425311/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a019/9425311/4b95e9935155/1072226.fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a019/9425311/985592ace516/1072226.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a019/9425311/b33775949dd7/1072226.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a019/9425311/4b95e9935155/1072226.fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a019/9425311/985592ace516/1072226.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a019/9425311/b33775949dd7/1072226.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a019/9425311/4b95e9935155/1072226.fig3.jpg

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Multiple myeloma hinders erythropoiesis and causes anaemia owing to high levels of CCL3 in the bone marrow microenvironment.多发性骨髓瘤由于骨髓微环境中 CCL3 水平升高而抑制红细胞生成并导致贫血。
Sci Rep. 2020 Nov 25;10(1):20508. doi: 10.1038/s41598-020-77450-y.
2
Transient Improvement in Erythropoiesis Is Achieved Via the Chaperone AHSP With Early Administration of Propranolol in Burn Patients.烧伤患者早期应用普萘洛尔通过伴侣蛋白 AHSP 实现红细胞生成的短暂改善。
J Burn Care Res. 2021 Mar 4;42(2):311-322. doi: 10.1093/jbcr/iraa150.
3
Autonomic nervous system control of multiple myeloma.
自主神经系统对多发性骨髓瘤的控制。
Blood Rev. 2021 Mar;46:100741. doi: 10.1016/j.blre.2020.100741. Epub 2020 Aug 11.
4
Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma.电子传递链活性是多发性骨髓瘤中 venetoclax 敏感性的预测因子和靶点。
Nat Commun. 2020 Mar 6;11(1):1228. doi: 10.1038/s41467-020-15051-z.
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Propranolol inhibits molecular risk markers in HCT recipients: a phase 2 randomized controlled biomarker trial.普萘洛尔抑制造血干细胞移植受者的分子风险标志物:一项2期随机对照生物标志物试验。
Blood Adv. 2020 Feb 11;4(3):467-476. doi: 10.1182/bloodadvances.2019000765.
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Multiple myeloma immunoglobulin lambda translocations portend poor prognosis.多发性骨髓瘤免疫球蛋白 λ 易位预示预后不良。
Nat Commun. 2019 Apr 23;10(1):1911. doi: 10.1038/s41467-019-09555-6.
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MAFb protein confers intrinsic resistance to proteasome inhibitors in multiple myeloma.MAFb 蛋白赋予多发性骨髓瘤对蛋白酶体抑制剂的固有耐药性。
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Myelo-erythroid commitment after burn injury is under β-adrenergic control via MafB regulation.烧伤后骨髓红系定向分化受β-肾上腺素能通过MafB调控。
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