产气克雷伯菌中胍丁胺降解酶及其合成的调控
Enzymes of agmatine degradation and the control of their synthesis in Klebsiella aerogenes.
作者信息
Friedrich B, Magasanik B
出版信息
J Bacteriol. 1979 Mar;137(3):1127-33. doi: 10.1128/jb.137.3.1127-1133.1979.
Abstract
The degradation of agmatine to succinate by Klebsiella aerogenes occurs in five steps. The enzyme catalyzing the first step, agmatinase, is induced by agmatine. The enzymes catalyzing the second and third steps, putrescine aminotransferase and 4-aminobutyraldehyde dehydrogenase, are induced by putrescine and also by their product, 4-aminobutyrate. The enzymes catalyzing the fourth and fifth steps, 4-aminobutyrate aminotransferase and succinate semialdehyde dehydrogenase, are induced by 4-aminobutyrate. This compound also serves as gratuitous inducer of the catabolic acetylornithine aminotransferase. The formation of the enzymes responsible for agmatine degradation is regulated not only by induction, but also by catabolite repression and activation by glutamine synthetase.
摘要
产气克雷伯菌将胍丁胺降解为琥珀酸的过程分五步进行。催化第一步反应的酶——胍丁胺酶，由胍丁胺诱导产生。催化第二步和第三步反应的酶——腐胺转氨酶和4-氨基丁醛脱氢酶，由腐胺及其产物4-氨基丁酸诱导产生。催化第四步和第五步反应的酶——4-氨基丁酸转氨酶和琥珀酸半醛脱氢酶，由4-氨基丁酸诱导产生。该化合物还作为分解代谢型乙酰鸟氨酸转氨酶的安慰诱导物。负责胍丁胺降解的酶的形成不仅受诱导调节，还受分解代谢物阻遏和谷氨酰胺合成酶的激活调节。
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本文引用的文献
1
Protein measurement with the Folin phenol reagent.
J Biol Chem. 1951 Nov;193(1):265-75.
2
PURIFICATION AND PROPERTIES OF A DIAMINE ALPHA-KETOGLUTARATE TRANSAMINASE FROM ESCHERICHIA COLI.
J Biol Chem. 1964 Mar;239:783-6.
3
ISOLATION AND PROPERTIES OF A PUTRESCINE-DEGRADING MUTANT OF ESCHERICHIA COLI.
J Bacteriol. 1963 Aug;86(2):320-3. doi: 10.1128/jb.86.2.320-323.1963.
4
Multiple pathways of putrescine biosynthesis in Escherichia coli.
J Biol Chem. 1966 Jul 10;241(13):3129-35.
5
Multiple molecular forms of glutamine synthetase produced by enzyme catalyzed adenylation and deadenylylation reactions.
Adv Enzyme Regul. 1970;8:99-118. doi: 10.1016/0065-2571(70)90011-7.
6
Resistance to catabolite repression of histidase and proline oxidase during nitrogen-limited growth of Klebsiella aerogenes.
J Biol Chem. 1971 Oct 25;246(20):6288-96.
7
Estimation of the molecular weights of proteins by Sephadex gel-filtration.
Biochem J. 1964 May;91(2):222-33. doi: 10.1042/bj0910222.
8
Role of 4-aminobutyrate aminotransferase in the arginine metabolism of Pseudomonas aeruginosa.
J Bacteriol. 1976 Dec;128(3):722-9. doi: 10.1128/jb.128.3.722-729.1976.
9
Utilization of arginine by Klebsiella aerogenes.
J Bacteriol. 1978 Feb;133(2):680-5. doi: 10.1128/jb.133.2.680-685.1978.
10
Catabolic N2-acetylornithine 5-aminotransferase of Klebsiella aerogenes: control of synthesis by induction, catabolite repression, and activation by glutamine synthetase.
J Bacteriol. 1978 Feb;133(2):686-91. doi: 10.1128/jb.133.2.686-691.1978.
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