Wu Jinlu, Gao Yihan, Li Dian, Gao Naiping
School of Mechanical Engineering, Tongji University, Shanghai 201804, China.
Shanghai New Tobacco Product Research Institute, Shanghai 201315, China.
Chem Res Toxicol. 2022 May 16;35(5):890-897. doi: 10.1021/acs.chemrestox.2c00076. Epub 2022 May 5.
Nicotine is a dependence-producing component in electronic cigarettes. The nicotine release characteristics of electronic cigarettes are closely connected with human exposure and respiratory health. In this paper, a theoretical model was established to study the effects of the compositions of e-liquids and the heating powers of device on the emission and gas/particle partitioning characteristics of nicotine in aerosols at equilibrium. The simulation results of nicotine emissions were compared with the experimental data. The errors between them were within a reasonable range. At a larger heating power level, a higher nicotine yield and a larger vaporization amount of e-liquids could be observed. Under the same heating power condition, a higher vegetable glycerin content in e-liquids could result in a lower nicotine emission. When the heating powers supplied by the device increased, a larger mass fraction of particle-phase nicotine in aerosols at equilibrium would appear. As more propylene glycol was added into e-liquids, a lower mass fraction of gas-phase nicotine would exist in aerosols at equilibrium. The results may provide more information for the industry to set technical standards for electronic cigarettes and for the government department to make regulatory policies.
尼古丁是电子烟中一种会导致成瘾的成分。电子烟的尼古丁释放特性与人体暴露及呼吸健康密切相关。本文建立了一个理论模型，以研究电子烟烟液成分和设备加热功率对平衡状态下气溶胶中尼古丁的释放及气/粒分配特性的影响。将尼古丁释放的模拟结果与实验数据进行了比较。两者之间的误差在合理范围内。在较高的加热功率水平下，可以观察到更高的尼古丁产率和更大的烟液汽化量。在相同的加热功率条件下，电子烟烟液中较高的植物甘油含量会导致较低的尼古丁释放量。当设备提供的加热功率增加时，平衡状态下气溶胶中颗粒相尼古丁的质量分数会更大。随着更多丙二醇添加到电子烟烟液中，平衡状态下气溶胶中气相聚尼古丁的质量分数会更低。这些结果可为行业制定电子烟技术标准以及政府部门制定监管政策提供更多信息。
