Department of Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA; Civitan International Research Center at UAB Heersink School of Medicine, Birmingham, AL, USA.
Department of Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA; Civitan International Research Center at UAB Heersink School of Medicine, Birmingham, AL, USA.
Neuron. 2022 May 4;110(9):1433-1435. doi: 10.1016/j.neuron.2022.04.007.
Genetic and environmental factors during development are involved in autism, and in this issue of Neuron Krüttner et al. (2022) find environment may play a more acute role in modulating autism behavior in a Shank3 exon 21 deletion mutant mouse (Shank3). The authors explore the underlying circuit mechanisms in detail.
遗传和环境因素在自闭症的发展中起作用，在本期《神经元》杂志上，Krüttner 等人（2022）发现环境可能在 Shank3 外显子 21 缺失突变小鼠（Shank3）中更急性地调节自闭症行为方面发挥更重要的作用。作者详细探讨了潜在的电路机制。
