Paris Cardiovascular Research Centre, Integrative Epidemiology of Cardiovascular Disease, INSERM U970, Université Paris Cité, Paris, France; Paris Sudden Death Expertise Centre (SDEC), Paris, France.
Copenhagen Emergency Medical Services, Copenhagen University Hospital, Copenhagen, Denmark; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte Hospital, Copenhagen, Denmark.
J Am Coll Cardiol. 2022 May 10;79(18):1818-1827. doi: 10.1016/j.jacc.2022.02.041.
Although sudden cardiac death (SCD) is recognized as a high-priority public health topic, reliable estimates of the incidence of SCD or, more broadly, out-of-hospital cardiac arrest (OHCA), in the population are scarce, especially in the European Union.
The study objective was to determine the incidence of SCD and OHCA in the European Union.
The study examined 4 large (ie, >2 million inhabitants) European population-based prospective registries collecting emergency medical services (EMS)-attended (ie, with attempted resuscitation) OHCA and SCD (OHCA without obvious extracardiac causes) for >5 consecutive years from January 2012 to December 2017 in the Paris region (France), the North Holland region (the Netherlands), the Stockholm region (Sweden), and in all of Denmark.
The average annual incidence of SCD in the 4 registries ranged from 36.8 per 100,000 (95% CI: 23.5-50.1 per 100,000) to 39.7 per 100,000 (95% CI: 32.6-46.8 per 100,000). When extrapolating to each European country and accounting for age and sex, this yields to 249,538 SCD cases per year (95% CI: 155,377-343,719 SCD cases per year). The average annual incidence of OHCA in the 4 registries ranged from 47.8 per 100,000 (95% CI: 21.2-74.4 per 100,000) to 57.9 per 100,000 (95% CI: 19.6-96.3 per 100,000), corresponding to 343,496 OHCA cases per year (95% CI: 216,472-464,922 OHCA cases per year) in the European Union. Incidence rates of SCD and OHCA increased with age and were systematically higher in men compared with women.
By combining data from 4 large, population-based registries with at least 5 years of data collection, this study provided an estimate of the incidence of SCD and OHCA in the European Union.
尽管心源性猝死（SCD）已被确认为一个高度优先的公共卫生议题，但在人群中，SCD 或更广泛的院外心脏骤停（OHCA）的可靠发生率数据仍然稀缺，尤其是在欧盟。
本研究旨在确定欧盟 SCD 和 OHCA 的发生率。
本研究调查了 4 个大型（即，超过 200 万居民）基于人群的前瞻性登记处，这些登记处从 2012 年 1 月至 2017 年 12 月，连续 5 年以上收集了接受紧急医疗服务（EMS）治疗的 OHCA（即，进行了复苏尝试）和 SCD（OHCA 无明显心外原因）的患者数据，这些登记处分别位于巴黎地区（法国）、北荷兰地区（荷兰）、斯德哥尔摩地区（瑞典）和丹麦全境。
4 个登记处的 SCD 平均年发生率范围为 36.8/100000（95%CI：23.5-50.1/100000）至 39.7/100000（95%CI：32.6-46.8/100000）。当外推至每个欧洲国家并考虑年龄和性别因素时，这相当于每年发生 249538 例 SCD（95%CI：155377-343719 例 SCD）。4 个登记处的 OHCA 平均年发生率范围为 47.8/100000（95%CI：21.2-74.4/100000）至 57.9/100000（95%CI：19.6-96.3/100000），相当于每年在欧盟发生 343496 例 OHCA（95%CI：216472-464922 例 OHCA）。SCD 和 OHCA 的发生率随年龄增长而增加，且男性明显高于女性。
通过合并至少 5 年数据收集的 4 个大型基于人群的登记处的数据，本研究提供了欧盟 SCD 和 OHCA 发生率的估计值。
