Division of Pulmonary and Critical Care Medicine, University of Texas Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.
Division of Pulmonary and Critical Care Medicine, Washington University in St. Louis, 4523 Clayton Avenue, Mailstop 8052-0043-14, St Louis, MO 63110, USA.
Thorac Surg Clin. 2022 May;32(2):221-229. doi: 10.1016/j.thorsurg.2021.12.003.
Rejection is a major complication following lung transplantation. Acute cellular rejection (ACR), and antibody-mediated rejection (AMR) are risk factors for the subsequent development of chronic lung allograft dysfunction and worse outcomes after transplantation. Although ACR has well-defined histopathologic diagnostic criteria and grading, the diagnosis of AMR requires a multidisciplinary diagnostic approach. This article reviews the identification, clinical and pathologic features of, and therapeutic options for ACR and AMR.
排斥反应是肺移植后的主要并发症。急性细胞排斥反应（ACR）和抗体介导的排斥反应（AMR）是随后发生慢性肺移植物功能障碍和移植后结局恶化的危险因素。虽然 ACR 具有明确的组织病理学诊断标准和分级，但 AMR 的诊断需要多学科的诊断方法。本文回顾了 ACR 和 AMR 的鉴定、临床和病理特征以及治疗选择。
