亚临床心血管疾病与多囊卵巢综合征。
Subclinical cardiovascular disease and polycystic ovary syndrome.
机构信息
Barbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars Sinai Medical Center, Los Angeles, California.
Department of Obstetrics and Gynecology, Cedars Sinai Medical Center, Los Angeles, California.
出版信息
Fertil Steril. 2022 May;117(5):912-923. doi: 10.1016/j.fertnstert.2022.02.028.
Abstract
Polycystic ovary syndrome (PCOS) impacts approximately 6%-10% of women worldwide, with hallmark features of hyperandrogenism, irregular menses, infertility, and polycystic appearing ovaries on ultrasound. In addition, PCOS is associated with several endocrine and metabolic disorders, including obesity, insulin resistance and diabetes mellitus, hypertension, dyslipidemia and metabolic syndrome, which all increase the risk for subclinical cardiovascular disease (CVD), the presence of altered vascular endothelium without overt CVD. In this review, we summarize the most recent literature regarding subclinical CVD in women with PCOS, including markers such as flow-mediated dilation, arterial stiffness, coronary artery calcium scores, carotid intima-media thickness and visceral and epicardial fat.
摘要
多囊卵巢综合征（PCOS）影响全球约 6%-10%的女性，其特征为高雄激素血症、月经不规律、不孕和超声下多囊卵巢。此外，PCOS 还与多种内分泌和代谢紊乱相关，包括肥胖、胰岛素抵抗和糖尿病、高血压、血脂异常和代谢综合征，所有这些都会增加亚临床心血管疾病（CVD）的风险，即存在血管内皮功能改变而无明显 CVD 的情况下。在这篇综述中，我们总结了关于 PCOS 女性亚临床 CVD 的最新文献，包括血流介导的扩张、动脉僵硬度、冠状动脉钙评分、颈动脉内膜中层厚度以及内脏和心外膜脂肪等标志物。
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Association of increased levels of omentin-1 and carotid intima-media thickness with early signs of cardiovascular risk in patients with polycystic ovary syndrome: A prospective case control study.网膜素-1 水平升高与颈动脉内膜中层厚度与多囊卵巢综合征患者心血管风险早期迹象的相关性：一项前瞻性病例对照研究。
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