Nisa Khair Ul, Tarfeen Najeebul, Mir Shahnaz Ahmad, Khurshid Zulaykha, Ahmad Mir Bilal, Wani Saba, Bhat Humaira, Ganai Bashir Ahmad
Department of Environmental Science, University of Kashmir, Srinagar, 190006 India.
Centre of Research for Development (CORD), University of Kashmir, Srinagar, 190006 India.
Indian J Clin Biochem. 2025 Apr;40(2):218-232. doi: 10.1007/s12291-023-01169-6. Epub 2023 Dec 24.
Polycystic ovarian syndrome is the most common endocrinopathy with heterogeneous symptomatology and diverse etiological links. Apart from genetic predisposition, environmental toxins, lifestyle, diet have been seen as contributing factors in shaping the disease. This study was taken to underpin the phenotypic status of PCOS in Kashmiri population and to compare their metabolic and endocrinological features. We explored the relationship between the junk food consumption patterns with the clinical features of PCOS phenotypes and controls. A total of 404 PCOS patients and 126 controls were recruited and cases were classified as per Rotterdam criteria. Anthropometric measurements and biochemical parameters of both cases and controls were taken. A detailed account on the type and frequency of outdoor foods eaten was focused and accordingly the study population was classified into voracious eaters, moderately eaters and rarely eaters of junk food. We found highest prevalence of phenotype A, n = 131 (32.8%) with full-blown symptoms in terms of obesity, IR, hirsutism, dyslipidemia and metabolic syndrome in our population. Phenotype D was found to be least prevalent n = 72 (17.7%) with milder form of symptoms. Our study is the first to unravel the phenotypic status of PCOS in Kashmiri population employing Rotterdam criteria and undertake dietary factor to relate with the pathogenesis of this disease. There was a notable association between an increasingly affluent diet, the presence of hirsutism, raised body mass index, obesity and metabolic syndrome in our population, making diet as an imperative factor to govern PCOS presentation. This study clearly implies the effect of unhealthy dietary habits to be associated with increasingly severe phenotype of PCOS, which can likely have implications on metabolic and fertility outcomes.
多囊卵巢综合征是最常见的内分泌疾病，症状多样，病因复杂。除了遗传易感性外，环境毒素、生活方式、饮食也被视为该疾病形成的促成因素。本研究旨在明确克什米尔人群中多囊卵巢综合征的表型状况，并比较其代谢和内分泌特征。我们探讨了垃圾食品消费模式与多囊卵巢综合征表型及对照组临床特征之间的关系。共招募了404例多囊卵巢综合征患者和126名对照，病例根据鹿特丹标准进行分类。对病例和对照进行了人体测量和生化参数检测。重点关注了所食用户外食品的类型和频率，并据此将研究人群分为垃圾食品的大量食用者、适度食用者和极少食用者。我们发现，在我们的人群中，A表型的患病率最高，n = 131（32.8%），在肥胖、胰岛素抵抗、多毛症、血脂异常和代谢综合征方面有典型症状。D表型的患病率最低，n = 72（17.7%），症状较轻。我们的研究首次采用鹿特丹标准明确了克什米尔人群中多囊卵巢综合征的表型状况，并探讨了饮食因素与该疾病发病机制的关系。在我们的人群中，日益丰富的饮食、多毛症、体重指数升高、肥胖和代谢综合征之间存在显著关联，这使得饮食成为影响多囊卵巢综合征表现的一个重要因素。这项研究清楚地表明，不健康的饮食习惯与多囊卵巢综合征日益严重的表型有关，这可能对代谢和生育结果产生影响。
