Kaik G, Witte P U
Wien Med Wochenschr. 1986 Dec 31;136(23-24):637-41.
Forskolin, a potent adenylate cyclase activating diterpene-derivative, isolated from the Indian plant Coleus forskohlii, was tested double-blind and cross-over in 12 healthy volunteers (nonsmokers) by whole body plethysmography. All drugs were administered by metered dose inhalers. The bronchodilating effect (after 5 minutes) was as good as following fenoterol. At the beginning (after 3 and 5 minutes) the protective effect against inhaled acetylcholine was as good as following fenoterol while later on (after 15 and 30 minutes) fenoterol resulted in a stronger action.
毛喉素是一种从印度植物毛喉鞘蕊花中分离出的强效激活腺苷酸环化酶的二萜类衍生物，通过全身体积描记法对12名健康志愿者（非吸烟者）进行双盲交叉试验。所有药物均通过定量吸入器给药。（5分钟后）其支气管扩张作用与非诺特罗相当。开始时（3分钟和5分钟后），其对吸入乙酰胆碱的保护作用与非诺特罗相当，但后来（15分钟和30分钟后），非诺特罗的作用更强。
