von Wichert P
Am Heart J. 1982 Aug;104(2 Pt 2):446-50. doi: 10.1016/0002-8703(82)90138-7.
In a double-blind, randomized crossover study of 12 patients suffering from chronic bronchitis, the comparative influence of equipotent doses of pindolol (5 mg) and metoprolol (100 mg) on the bronchodilatory potential of inhaled fenoterol (0.4 mg), a beta 2-agonist, was investigated by means of body plethysmography. Neither beta-blocker caused bronchospasm or attenuated the bronchodilation due to fenoterol. The results are not pertinent to the potential risk of bronchospastic complications induced by beta 1-selective or nonselective drugs, but they rule out a therapy-oriented differentiation between pindolol and cardioselective agents as far as the potential response to the bronchodilating activity of inhaled sympathomimetics is concerned.
在一项针对12例慢性支气管炎患者的双盲随机交叉研究中，通过体积描记法研究了等效剂量的吲哚洛尔（5毫克）和美托洛尔（100毫克）对吸入β2激动剂非诺特罗（0.4毫克）的支气管扩张潜力的比较影响。两种β受体阻滞剂均未引起支气管痉挛，也未减弱非诺特罗所致的支气管扩张。这些结果与β1选择性或非选择性药物引起支气管痉挛并发症的潜在风险无关，但就吸入拟交感神经药的支气管扩张活性的潜在反应而言，排除了吲哚洛尔与心脏选择性药物之间基于治疗的差异。
