Ryu Ji Young, Sunwoo Yu Eun, Lee Sang-Yoon, Lee Chae-Kwan, Kim Jeong-Ho, Lee Jong-Tae, Kim Dae-Hwan
a Department of Occupational and Environmental Medicine , Inje University Haeundae Paik Hospital , Busan , South Korea.
COPD. 2015 Aug;12(4):374-80. doi: 10.3109/15412555.2014.949000.
To evaluate the association between the risk of chronic obstructive pulmonary disease (COPD) and exposure to vapors, gases, dusts, or fumes (VGDF), we conducted a meta-analysis of epidemiological studies. We searched for studies investigating the relationship between COPD and occupational exposure to VGDF in the adult population. The bibliographic search was conducted in databases (PubMed and Google Scholar). Eleven studies that met predetermined inclusion criteria were included in the meta-analysis. We calculated the pooled odds ratio (OR) with its 95% confidence interval (CI) of COPD for exposure to VGDF using a random-effects model. The presence of publication bias was explored. There was moderate heterogeneity among the included studies (I(2) = 54.3%). In a random-effects model meta-analysis, the pooled OR for exposure to VGDF was 1.43 for COPD (95% CI: 1.19-1.73) compared with no exposure to VGDF. Publication bias was not observed in this study. Our study suggests that exposure to VGDF is associated with a higher risk of COPD. Further prospective cohort studies are needed to confirm this association.
为评估慢性阻塞性肺疾病（COPD）风险与接触蒸汽、气体、粉尘或烟雾（VGDF）之间的关联，我们对流行病学研究进行了一项荟萃分析。我们检索了调查成年人群中COPD与职业性接触VGDF之间关系的研究。文献检索在数据库（PubMed和谷歌学术）中进行。荟萃分析纳入了11项符合预定纳入标准的研究。我们使用随机效应模型计算了接触VGDF的COPD合并比值比（OR）及其95%置信区间（CI）。探讨了发表偏倚的存在情况。纳入的研究之间存在中度异质性（I² = 54.3%）。在随机效应模型荟萃分析中，与未接触VGDF相比，接触VGDF的COPD合并OR为1.43（95%CI：1.19 - 1.73）。本研究未观察到发表偏倚。我们的研究表明，接触VGDF与COPD风险较高相关。需要进一步的前瞻性队列研究来证实这种关联。
