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使用 IMPT 提高靶区覆盖率的同时保护视交叉和神经的推量头盔治疗病例研究

Case study of a bolus helmet used to maintain optic chiasm and nerve sparing while improving target coverage using IMPT.

机构信息

Medical Dosimetry Program at the University of Wisconsin La-Crosse, WI, USA; University of Wisconsin La Crosse, Health Professions Department, LaCrosse, WI, 54601, USA.

Medical Dosimetry Program at the University of Wisconsin La-Crosse, WI, USA; University of Wisconsin La Crosse, Health Professions Department, LaCrosse, WI, 54601, USA.

出版信息

Med Dosim. 2022;47(3):242-246. doi: 10.1016/j.meddos.2022.03.003. Epub 2022 May 2.

DOI:10.1016/j.meddos.2022.03.003
PMID:35513997
Abstract

The purpose of this study was to examine if the use of a bolus helmet when treating the head with intensity modulated proton therapy (IMPT) will maintain organs at risk (OAR) sparing while improving the clinical target volume (CTV) coverage. A bolus helmet is a device that aims to improve on the traditionally used range shifter in proton therapy by improving dose distribution characteristics. Ten patients were retrospectively selected who had 2 separate treatment planning scans performed, a scan with the bolus helmet and a second scan without. Plans were created using both scans. Dose to organs at risk (OAR) including the left optic nerve, right optic nerve, optic chiasm, and normal brain minus CTV (brain-CTV), as well as CTV coverage were compared between the 2 plans. The use of the bolus helmet displayed lower mean OAR doses as well as higher CTV coverage, suggesting that use of the bolus helmet provides benefit when treating the head with IMPT.

摘要

本研究旨在探讨在强度调制质子治疗(IMPT)中使用束流帽治疗头部时,是否可以在保持危及器官(OAR)免受照射的同时改善临床靶区(CTV)的覆盖范围。束流帽是一种旨在通过改善剂量分布特性来改进质子治疗中传统使用的射野挡块的设备。回顾性选择了 10 名患者,对他们进行了 2 次单独的治疗计划扫描,一次是使用束流帽的扫描,另一次是不使用束流帽的扫描。使用这两种扫描方法都创建了计划。比较了两种计划中 OAR(包括左眼神经、右眼神经、视交叉和正常脑减去 CTV(脑CTV))的剂量以及 CTV 的覆盖范围。使用束流帽可以降低 OAR 的平均剂量,同时提高 CTV 的覆盖范围,这表明在使用 IMPT 治疗头部时,使用束流帽是有益的。

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