Zhou Fangyan, Chen Shisheng, Jin Wanwan, Lu Yuwen, Gao Yu, Wu Jianming
Yuying Children's Hospital, The second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Dermatol Ther. 2022 Jul;35(7):e15556. doi: 10.1111/dth.15556. Epub 2022 May 29.
Vitiligo is an acquired depigmenting disorder in which destruction of skin melanocytes. In recent years, 308-nm excimer laser (308-nm EL) and topical tacrolimus have been extensively used to treat vitiligo. This study aimed to investigate the effectiveness and safety of combined treatment of 308-nm EL and topical tacrolimus for treating periocular vitiligo compared to 308-nm EL monotherapy. This study is a retrospective observational study, involving 58 Chinese patients of periocular vitiligo, divided into two groups: the control group (28 patients) treated with 308-nm EL; and the experimental group (30 patients) treated with 308-nm EL and topical tacrolimus 0.1% ointment. Repigmentation was assessed at four grades. In the control group, there were four patients (14%) with poor repigmentation, eleven patients (39%) with moderate repigmentation, ten patients (36%) with good repigmentation, three patients (11%) with excellent repigmentation. In the experimental group, two patients (7%) experienced poor repigmentation, six patients (20%) experienced moderate repigmentation, fifteen patients (50%) experienced good repigmentation, seven patients (23%) experienced excellent repigmentation. The experimental group efficacy rate (good and excellent repigmentation) was 73.3%, higher than 46.4% for the control group (p = 0.037). Our findings suggest that both treatments are safe and the combination of tacrolimus and 308-nm EL is more effective than 308-nm EL alone for periocular vitiligo.
白癜风是一种后天性色素脱失性疾病，其特征为皮肤黑素细胞遭到破坏。近年来，308纳米准分子激光（308-nm EL）和外用他克莫司已被广泛用于治疗白癜风。本研究旨在探讨308-nm EL联合外用他克莫司治疗眼周白癜风的有效性和安全性，并与308-nm EL单一疗法进行比较。本研究为一项回顾性观察性研究，纳入58例中国眼周白癜风患者，分为两组：对照组（28例患者）接受308-nm EL治疗；实验组（30例患者）接受308-nm EL联合0.1%外用他克莫司软膏治疗。根据色素恢复情况分为四个等级进行评估。对照组中，色素恢复差的有4例（14%），中度恢复的有11例（39%），恢复良好的有10例（36%），恢复极佳的有3例（11%）。实验组中，色素恢复差的有2例（7%），中度恢复的有6例（20%），恢复良好的有15例（50%），恢复极佳的有7例（23%）。实验组的有效率（恢复良好和极佳）为73.3%，高于对照组的46.4%（p = 0.037）。我们的研究结果表明，两种治疗方法均安全，且他克莫司与308-nm EL联合使用治疗眼周白癜风比单独使用308-nm EL更有效。
