Hu Yu, Xu Zhuohong, Liu Lihao, Ju Mei, Luan Chao, Chen Hongying, Chen Lihao, Dai Xiaoxi, Zhang Liangliang, Huang Dan, Zhang Jiaan, Chen Kun
Department of Physiotherapy, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, 210042, China.
Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, 210042, China.
Arch Dermatol Res. 2025 Jan 9;317(1):210. doi: 10.1007/s00403-024-03721-7.
Previous studies have proven that 308-nm light-emitting diode(308-nm LED)and 308-nm excimer lamp(308-nm MEL) are effective in treating vitiligo, but there is a lack of comparison of their efficacy for facial lesions.
To evaluate and contrast the treatment success rates of 308-nm LED versus 308-nm excimer lamp in managing facial lesions among patients suffering from stable non-segmental vitiligo.
The enrolled 119 patients with 145 lesions were randomly assigned to receive 308-nm LED or 308-nm MEL for two months. Two independent investigators graded repigmentation at the end of the 2-month treatment period.
There were 76 lesions in the 308-nm LED group and 69 in the 308-nm MEL group. After 1 month, the average repigmentation grade of the 308-nm LED group was 1.34, with an efficacy rate of 11.84%, and the average repigmentation grade of the 308-nm MEL group was 1.17, with an efficacy rate of 7.24%.After two months of phototherapy, the average repigmentation grade of the 308-nm LED group was 2.38, and the effective rate was 42.1%. The average repigmentation grade in the 308-nm MEL group was 2.19, and the effective rate was 39.12%. The two light sources had similar effects on facial vitiligo lesions after 1 month and 2 months of treatment(P =.349, P =.416), and the incidence of side effects was also comparable between the two groups (P =.332).
The 308-nm LED is as effective and safe as 308-nm MEL in treating stable non-segmental facial vitiligo lesions.
既往研究已证实，308纳米发光二极管（308-nm LED）和308纳米准分子灯（308-nm MEL）在治疗白癜风方面有效，但缺乏对其对面部皮损疗效的比较。
评估并对比308-nm LED与308-nm准分子灯治疗稳定期非节段型白癜风患者面部皮损的成功率。
将纳入的119例患者的145处皮损随机分配，接受308-nm LED或308-nm MEL治疗两个月。两名独立研究者在2个月治疗期结束时对色素恢复情况进行分级。
308-nm LED组有76处皮损，308-nm MEL组有69处皮损。1个月后，308-nm LED组的平均色素恢复分级为1.34，有效率为11.84%；308-nm MEL组的平均色素恢复分级为1.17，有效率为7.24%。光疗2个月后，308-nm LED组的平均色素恢复分级为2.38，有效率为42.1%。308-nm MEL组的平均色素恢复分级为2.19，有效率为39.12%。治疗1个月和2个月后，两种光源对面部白癜风皮损的效果相似（P = 0.349，P = 0.416），两组间副作用发生率也相当（P = 0.332）。
308-nm LED在治疗稳定期非节段型面部白癜风皮损方面与第308-nm MEL同样有效且安全。
