Hamm K D, Beer R, Pothe H
Zentralbl Neurochir. 1986;47(4):322-33.
A total of 48 end-to-side microvascular anastomoses between the A. and the V. femoralis of Albino Wistar rats were established with and without an additional gluing using the human plasma fraction Cohn I (Cohn-I adhesive) and clinically and histologically examined after 3-4 weeks--group 1 with 4 single button sutures and gluing, group 2 with 8 single button sutures and gluing as well as a control group with the usual suture technique with 12-14 single knob sutures (in each case 16 anastomoses). The time required for anastomosing could not be considerably reduced by the suture-gluing technique. In group 1 the thrombotic occlusion due to vascular wall dehiscences with penetration of the adhesive material into the lumen could not be prevented in eight anastomoses. Owing to the exact vascular wall adaptation with 8 single button (group 2) 14 anastomoses were free just as in the control group. Histologically the tissue-preserving influence of the gluing could be confirmed by the reduction of the number of sutures. Summarising it can be said that the perfectly performed suture technique should continue to play the dominating role, but that the combined suture-gluing technique can be a great help for the surgeon in special cases.
对白化Wistar大鼠的股动脉和股静脉进行了总共48次端侧微血管吻合，分别采用了使用人血浆组分科恩I（科恩-I粘合剂）和不使用额外粘合的方法，并在3至4周后进行了临床和组织学检查——第1组采用4根单纽扣缝线并粘合，第2组采用8根单纽扣缝线并粘合，以及采用常规缝合技术使用12 - 14根单结缝线的对照组（每组各16个吻合口）。缝合 - 粘合技术并不能显著减少吻合所需的时间。在第1组中，8个吻合口因血管壁裂开且粘合剂材料渗入管腔而无法预防血栓形成性闭塞。由于采用8根单纽扣缝线（第2组）能使血管壁精确对合，14个吻合口如同对照组一样通畅。组织学上，通过减少缝线数量可证实粘合对组织的保护作用。总而言之，可以说完美执行的缝合技术应继续起主导作用，但缝合 - 粘合联合技术在特殊情况下对外科医生会有很大帮助。
