Fietta A, Sacchi F, Bersani C, Gialdroni Grassi G, Stronati M, Gancia P, Rondini G
Acta Paediatr Scand. 1987 Jan;76(1):37-41. doi: 10.1111/j.1651-2227.1987.tb10411.x.
Complement-dependent serum bactericidal activity for E. coli K12 was assessed in 12 term infants and in 16 preterm infants. In both groups of newborns, at birth, bactericidal reaction by the classical pathway of complement activation was impaired with respect to normal controls at less than 0.001 level of significance (as estimated by Student's t-test). The serum bactericidal reaction by the alternative pathway of complement activation was significantly impaired only in preterm newborns, being normal in term infants. At a time corresponding to 40 weeks' gestational age also in preterm newborns alternative pathway mediated bactericidal activity for E. coli K12 was found normal. Classical pathway mediated bactericidal activity became normal only at an age corresponding to 52 weeks' gestational age.
对12名足月儿和16名早产儿评估了针对大肠杆菌K12的补体依赖性血清杀菌活性。在两组新生儿中，出生时，补体激活经典途径的杀菌反应相对于正常对照组在显著性水平小于0.001时受损（通过学生t检验估计）。补体激活替代途径的血清杀菌反应仅在早产儿中显著受损，足月儿中正常。在相当于孕40周时，早产儿针对大肠杆菌K12的替代途径介导的杀菌活性也正常。经典途径介导的杀菌活性仅在相当于孕52周的年龄时才正常。
