Medical School, Southeast University, Nanjing, China.
Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China.
Front Immunol. 2022 Apr 19;13:849451. doi: 10.3389/fimmu.2022.849451. eCollection 2022.
The rapid development of multiple high-throughput sequencing technologies has made it possible to explore the critical roles and mechanisms of functional enhancers and enhancer RNAs (eRNAs). The inflammatory immune response, as a fundamental pathological process in infectious diseases, cancers and immune disorders, coordinates the balance between the internal and external environment of the organism. It has been shown that both active enhancers and intranuclear eRNAs are preferentially expressed over inflammation-related genes in response to inflammatory stimuli, suggesting that enhancer transcription events and their products influence the expression and function of inflammatory genes. Therefore, in this review, we summarize and discuss the relevant inflammatory roles and regulatory mechanisms of eRNAs in inflammatory immune cells, non-inflammatory immune cells, inflammatory immune diseases and tumors, and explore the potential therapeutic effects of enhancer inhibitors affecting eRNA production for diseases with inflammatory immune responses.
多种高通量测序技术的快速发展使得探索功能增强子和增强子 RNA（eRNAs）的关键作用和机制成为可能。炎症免疫反应作为传染病、癌症和免疫紊乱的基本病理过程，协调了机体内外环境的平衡。研究表明，活性增强子和核内 eRNAs 在外源炎症刺激下优先表达于炎症相关基因，提示增强子转录事件及其产物影响炎症基因的表达和功能。因此，在本综述中，我们总结和讨论了 eRNAs 在炎症免疫细胞、非炎症免疫细胞、炎症性免疫疾病和肿瘤中的相关炎症作用和调控机制，并探讨了影响 eRNA 产生的增强子抑制剂在具有炎症免疫反应的疾病中的潜在治疗效果。
