MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
Int J Mol Sci. 2022 Sep 30;23(19):11582. doi: 10.3390/ijms231911582.
Enhancer RNAs (eRNAs), a class of non-coding RNAs (ncRNAs) transcribed from enhancer regions, serve as a type of critical regulatory element in gene expression. There is increasing evidence demonstrating that the aberrant expression of eRNAs can be broadly detected in various human diseases. Some studies also revealed the potential clinical utility of eRNAs in these diseases. In this review, we summarized the recent studies regarding the pathological mechanisms of eRNAs as well as their potential utility across human diseases, including cancers, neurodegenerative disorders, cardiovascular diseases and metabolic diseases. It could help us to understand how eRNAs are engaged in the processes of diseases and to obtain better insight of eRNAs in diagnosis, prognosis or therapy. The studies we reviewed here indicate the enormous therapeutic potency of eRNAs across human diseases.
增强子 RNA（eRNA）是一类从增强子区域转录而来的非编码 RNA（ncRNA），作为基因表达的关键调控元件之一。越来越多的证据表明，eRNA 的异常表达可以在各种人类疾病中广泛检测到。一些研究还揭示了 eRNA 在这些疾病中的潜在临床应用。在这篇综述中，我们总结了最近关于 eRNA 的病理机制及其在包括癌症、神经退行性疾病、心血管疾病和代谢性疾病等人类疾病中的潜在应用的研究。这有助于我们了解 eRNA 如何参与疾病的发生过程，并深入了解 eRNA 在诊断、预后或治疗中的作用。我们在这里回顾的研究表明，eRNA 在人类疾病中具有巨大的治疗潜力。
