Division of Translational Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria.
Department of Neurology, Klinik Floridsdorf, Wien, Austria.
Front Immunol. 2022 Apr 20;13:863568. doi: 10.3389/fimmu.2022.863568. eCollection 2022.
This review focuses on current clinical and immunological aspects of cerebral malaria induced by infection. Albeit many issues concerning the inflammatory responses remain unresolved and need further investigations, current knowledge of the underlying molecular mechanisms is highlighted. Furthermore, and in the light of significant limitations in preventative diagnosis and treatment of cerebral malaria, this review mainly discusses our understanding of immune mechanisms in the light of the most recent research findings. Remarkably, the newly proposed CD8+ T cell-driven pathophysiological aspects within the central nervous system are summarized, giving first rational insights into encouraging studies with immune-modulating adjunctive therapies that protect from symptomatic cerebral participation of infection.
这篇综述聚焦于 感染引起的脑型疟疾的当前临床和免疫学方面。尽管许多关于炎症反应的问题仍未解决，需要进一步研究，但目前对潜在分子机制的认识已被强调。此外，鉴于在预防诊断和治疗脑型疟疾方面存在重大局限性，这篇综述主要根据最新的研究结果讨论了我们对免疫机制的理解。值得注意的是，总结了中枢神经系统中新近提出的 CD8+ T 细胞驱动的病理生理方面，为具有免疫调节辅助治疗的令人鼓舞的研究提供了初步的合理见解，这些研究可预防 感染引起的有症状的中枢神经系统受累。
