Stjernquist-Desatnik A, Kurl D N, Christensen P
Acta Pathol Microbiol Immunol Scand B. 1986 Dec;94(6):405-8. doi: 10.1111/j.1699-0463.1986.tb03075.x.
Group A streptococcal strains (three T-type 1, two T-type 2 and three T-type 4), freshly isolated from throat cultures, were subjected to 25 serial passages on blood agar. All strains changed their M protein production and/or opacity factor (OF)-activity during the passages. The capacity of each strain to adhere to a pool of buccal cells from six healthy individuals was studied both before and after passage. Five of six strains with decreased OF-activity/M protein production diminished significantly in adherence capacity, whereas one of two strains with increasing OF-activity adhered better to the epithelial cells. The results are discussed in relation to the clinical view of asymptomatic carriers of group A streptococci.
从咽喉培养物中新鲜分离出的A组链球菌菌株（三株T1型、两株T2型和三株T4型），在血琼脂上进行了25次连续传代。所有菌株在传代过程中其M蛋白产生和/或透明质酸酶（OF）活性均发生了变化。在传代前后，研究了各菌株粘附来自六名健康个体的颊细胞池的能力。六株OF活性/M蛋白产生降低的菌株中有五株的粘附能力显著降低，而两株OF活性增加的菌株中有一株对上皮细胞的粘附性更好。结合A组链球菌无症状携带者的临床观点对结果进行了讨论。
