Sabbah H N, Przybylski J, Albert D E, Stein P D
Am Heart J. 1987 Apr;113(4):885-90. doi: 10.1016/0002-8703(87)90048-2.
Peak aortic blood velocity (Vel), peak acceleration (Acc), stroke volume (SV), and left ventricular (LV) ejection fraction (EF) have been used as noninvasive indicators of global LV performance. The purpose of this study was to determine which of these indices of LV performance relates best to the extent of LV ischemic mass at risk. Studies were performed in 24 open-chest anesthetized dogs. Acute ischemia was produced by occlusion of various levels of the left anterior descending and circumflex coronary arteries. LV ischemic mass, measured as a percent of total LV mass, was delineated by injection of Evans blue dye into the nonischemic zone. Acc and Vel were measured with continuous-wave Doppler ultrasound. EF was measured angiographically. All parameters were measured during a control period and within 6 minutes of coronary occlusion. The percent change during ischemia of each parameter relative to control (% delta) was calculated. The correlation coefficient between the percent ischemic mass at risk and % delta Acc was 0.88. It was 0.84 for % delta EF, 0.77 for % delta Vel, and 0.17 for % delta SV. These results indicate that among the various global indices of LV performance that have been used noninvasively, Acc correlates most closely with the extent of LV ischemic mass at risk.
主动脉血流峰值速度（Vel）、峰值加速度（Acc）、每搏输出量（SV）以及左心室（LV）射血分数（EF）已被用作评估左心室整体功能的无创指标。本研究的目的是确定这些左心室功能指标中哪一项与处于风险中的左心室缺血心肌范围的相关性最佳。对24只开胸麻醉犬进行了研究。通过闭塞不同水平的左前降支和左旋支冠状动脉制造急性缺血。通过向非缺血区注射伊文思蓝染料来界定左心室缺血心肌，以左心室总质量的百分比来衡量。使用连续波多普勒超声测量Acc和Vel。通过血管造影测量EF。在对照期以及冠状动脉闭塞后6分钟内测量所有参数。计算每个参数在缺血期间相对于对照的变化百分比（%变化）。处于风险中的缺血心肌百分比与%变化Acc之间的相关系数为0.88。%变化EF为0.84，%变化Vel为0.77，%变化SV为0.17。这些结果表明，在已被无创使用的各种左心室整体功能指标中，Acc与处于风险中的左心室缺血心肌范围的相关性最为密切。
