Rasool Atta, Ata Sadia, Islam Atif, Khan Rafi Ullah
Institute of Chemistry, University of the Punjab P. O. Box, 54590 Lahore Pakistan
Department of Polymer Engineering and Technology, University of the Punjab P. O. Box, 54590 Lahore Pakistan
RSC Adv. 2019 Apr 17;9(22):12282-12290. doi: 10.1039/c9ra02130b.
Kappa carrageenan was used to prepare hydrogels having novel compositions with poly(vinyl alcohol) (PVA) and a crosslinker (3-aminopropyl)triethoxysilane (APTES). FTIR was used to confirm the structure and composition of hydrogels. The swelling behavior of hydrogels was studied under different conditions of pH and electrolytic aqueous media. The most efficient swelling result (200%) was observed by the sample containing a low fraction of crosslinker. It also showed different swelling responses in different pH solutions that made it suitable for drug delivery. Thermogravimetric analysis (TGA) illustrated that with the increase in crosslinker amount, the stability of hydrogel was increased. The biodegradation analysis of the hydrogels exhibited the break down by various enzymes into small chain polysaccharides that further broke down in the metabolic pathways. It was revealed that all the hydrogel samples showed strong antibacterial activity against and a little against . Cephradine was used as a model drug and its release was studied in simulated intestinal fluids (SIF). This release account of the cephradine demonstrated that the release of the drug increased as the time and pH increased, reaching its maximum amount of 85.5% after 7.5 h.
κ-卡拉胶用于制备具有新型组成的水凝胶，其与聚乙烯醇（PVA）和交联剂（3-氨丙基）三乙氧基硅烷（APTES）混合。傅里叶变换红外光谱（FTIR）用于确认水凝胶的结构和组成。研究了水凝胶在不同pH值和电解质水溶液介质条件下的溶胀行为。含有低比例交联剂的样品观察到最有效的溶胀结果（200%）。它在不同pH值溶液中也表现出不同的溶胀响应，这使其适用于药物递送。热重分析（TGA）表明，随着交联剂用量的增加，水凝胶的稳定性增强。水凝胶的生物降解分析表明，各种酶将其分解为小链多糖，这些小链多糖在代谢途径中进一步分解。结果表明，所有水凝胶样品对[具体细菌1]表现出较强的抗菌活性，对[具体细菌2]表现出较弱的抗菌活性。头孢拉定用作模型药物，并在模拟肠液（SIF）中研究其释放情况。头孢拉定的这种释放情况表明，药物释放量随时间和pH值的增加而增加，7.5小时后达到最大释放量85.5%。
