Mohd Amin Mohd Cairul Iqbal, Ahmad Naveed, Pandey Manisha, Jue Xin Chong
Faculty of Pharmacy, Centre for Drug Delivery Research, Universiti Kebangsaan Malaysia , Kuala Lumpur , Malaysia.
Drug Dev Ind Pharm. 2014 Oct;40(10):1340-9. doi: 10.3109/03639045.2013.819882. Epub 2013 Jul 22.
This study evaluated the potential of stimuli-responsive bacterial cellulose-g-poly(acrylic acid-co-acrylamide) hydrogels as oral controlled-release drug delivery carriers. Hydrogels were synthesized by graft copolymerization of the monomers onto bacterial cellulose (BC) fibers by using a microwave irradiation technique. The hydrogels were characterized by Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). FT-IR spectroscopy confirmed the grafting. XRD showed that the crystallinity of BC was reduced by grafting, whereas an increase in the thermal stability profile was observed in TGA. SEM showed that the hydrogels exhibited a highly porous morphology, which is suitable for drug loading. The hydrogels demonstrated a pH-responsive swelling behavior, with decreased swelling in acidic media, which increased with increase in pH of the media, reaching maximum swelling at pH 7. The release profile of the hydrogels was investigated in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). The hydrogels showed lesser release in SGF than in SIF, suggesting that hydrogels may be suitable drug carriers for oral controlled release of drug delivery in the lower gastrointestinal tract.
本研究评估了刺激响应性细菌纤维素接枝聚（丙烯酸 - 共 - 丙烯酰胺）水凝胶作为口服控释药物递送载体的潜力。通过使用微波辐照技术将单体接枝共聚到细菌纤维素（BC）纤维上来合成水凝胶。通过傅里叶变换红外（FT - IR）光谱、X射线衍射（XRD）、热重分析（TGA）和扫描电子显微镜（SEM）对水凝胶进行了表征。FT - IR光谱证实了接枝反应。XRD表明接枝后BC的结晶度降低，而TGA显示热稳定性有所提高。SEM表明水凝胶呈现出高度多孔的形态，适合药物负载。水凝胶表现出pH响应性溶胀行为，在酸性介质中溶胀减小，随着介质pH值的增加而增大，在pH 7时达到最大溶胀。在模拟胃液（SGF）和模拟肠液（SIF）中研究了水凝胶的释放曲线。水凝胶在SGF中的释放比在SIF中少，表明水凝胶可能是用于下消化道口服控释药物递送的合适药物载体。
