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紫杉醇与吉西他滨的共递送：一种用于靶向治疗乳腺癌的自组装纳米颗粒

Co-delivery of paclitaxel and gemcitabine a self-assembling nanoparticle for targeted treatment of breast cancer.

作者信息

Lei Meng, Sha Sijia, Wang Xueyuan, Wang Jia, Du Xiao, Miao Hang, Zhou Hui, Bai Enhe, Shi Jingmiao, Zhu Yongqiang

机构信息

College of Science, Nanjing Forestry University No. 159 Longpan Road Nanjing 210037 PR China.

College of Life Science, Nanjing Normal University No. 1 Wenyuan Road Nanjing 210046 PR China

出版信息

RSC Adv. 2019 Feb 13;9(10):5512-5520. doi: 10.1039/c9ra00276f. eCollection 2019 Feb 11.

DOI:10.1039/c9ra00276f
PMID:35515924
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9060788/
Abstract

Multi-functional nanoparticles can be used to improve the treatment index and reduce side effects of anti-tumor drugs. Herein, we developed a kind of multi-functional and highly biocompatible nanoparticle (NP) loaded with folic acid (FA), paclitaxel (PTX) and gemcitabine (GEM) self-assembly to target cancer cells. The transmission electron microscopy (TEM) results showed that multi-functional FA targeting nanoparticles (MF-FA NPs) exhibited spherical morphology and favorable structural stability in aqueous solution. In addition, NPs (MF-FA NPs and MF NPs) exhibited comparable proliferation inhibition to breast cancer cell 4T1 compared with the pure drug. In antitumor studies, NPs showed an obviously enhanced anti-tumor efficacy compared with the pure drug. Furthermore, MF-FA NPs displayed higher tumor growth inhibition than MF NPs due to the specific targeting of FA to cancer cells. Consequently, the novel MF-FA NPs could be used as a potential chemotherapeutic formulation for breast cancer therapy.

摘要

多功能纳米颗粒可用于提高抗肿瘤药物的治疗指数并减少其副作用。在此，我们开发了一种负载叶酸（FA）、紫杉醇（PTX）和吉西他滨（GEM）的多功能且具有高度生物相容性的纳米颗粒（NP）自组装体，用于靶向癌细胞。透射电子显微镜（TEM）结果表明，多功能FA靶向纳米颗粒（MF-FA NPs）呈现球形形态，且在水溶液中具有良好的结构稳定性。此外，与纯药物相比，纳米颗粒（MF-FA NPs和MF NPs）对乳腺癌细胞4T1表现出相当的增殖抑制作用。在抗肿瘤研究中，纳米颗粒与纯药物相比显示出明显增强的抗肿瘤疗效。此外，由于FA对癌细胞的特异性靶向作用，MF-FA NPs比MF NPs表现出更高的肿瘤生长抑制作用。因此，新型MF-FA NPs可作为一种潜在的用于乳腺癌治疗的化疗制剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf2f/9060788/ca9aae3854e9/c9ra00276f-f9.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf2f/9060788/603691de9f56/c9ra00276f-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf2f/9060788/ca9aae3854e9/c9ra00276f-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf2f/9060788/3e2703b8810c/c9ra00276f-f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf2f/9060788/96dbbe8a8258/c9ra00276f-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf2f/9060788/2a33e1ff9b04/c9ra00276f-f5.jpg
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1
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Anticancer Drugs. 2018 Aug;29(7):637-645. doi: 10.1097/CAD.0000000000000631.
2
Efficacy of paclitaxel/dexamethasone intra-tumoral delivery in treating orthotopic mouse breast cancer.紫杉醇/地塞米松瘤内给药治疗原位小鼠乳腺癌的疗效。
J Control Release. 2018 Jun 10;279:1-7. doi: 10.1016/j.jconrel.2018.04.010. Epub 2018 Apr 11.
3
Erythrocyte Membrane-Wrapped pH Sensitive Polymeric Nanoparticles for Non-Small Cell Lung Cancer Therapy.
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Molecules. 2023 Nov 24;28(23):7767. doi: 10.3390/molecules28237767.
4
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ACS Omega. 2023 Sep 12;8(38):34481-34498. doi: 10.1021/acsomega.3c02901. eCollection 2023 Sep 26.
5
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Front Pharmacol. 2023 Jul 28;14:1184472. doi: 10.3389/fphar.2023.1184472. eCollection 2023.
6
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5
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6
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7
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