Demircioglu Zeynep Gul, Demircioglu Mahmut Kaan, Aygun Nurcihan, Akgun Ismail Ethem, Unlu Mehmet Taner, Kostek Mehmet, Ozguven Muveddet Banu Yilmaz, Uludag Mehmet
Department of General Surgery, Health Ministry of Turkish Republic, Kars Harakani State Hospital, Kars, Turkey.
Department of General Surgery, University of Health Sciences Turkey, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.
Sisli Etfal Hastan Tip Bul. 2022 Mar 28;56(1):126-131. doi: 10.14744/SEMB.2022.14554. eCollection 2022.
Thyroid-stimulating hormones (TSHs) are associated with the risk of differentiated thyroid cancer. The relationship between pre-operative TSH levels and aggressive features is unclear. We aimed to evaluate the relationship between pathological features of papillary thyroid carcinoma (PTC) and high TSH levels.
Patients who were operated between 2012 and 2017 and who were found to have PTC in their pathology were included in the study. The relationship between TSH and the features of tumor aggressiveness was evaluated in the patients.
Of the 132 patients, TSH level was significantly higher in those with lymphovascular invasion than those without (p=0.048), in those with central metastases than in those without (p=0.014), and in those with extrathyroidal spread than in those without (p=0.003). When patients were categorized into four 25% quartiles according to TSH (mUI/mL) level; the rate of extrathyroidal invasion increased as the TSH level increased, and the level was significantly higher in quartile 1 than the others, with significant difference (p=0.030).
Pre-operative increase in TSH level is associated with an increased risk of extrathyroidal spread and central lymph node metastasis. TSH level may be a pre-operative valuable predictive factor for patients' risk of central metastasis.
促甲状腺激素（TSH）与分化型甲状腺癌的风险相关。术前TSH水平与侵袭性特征之间的关系尚不清楚。我们旨在评估甲状腺乳头状癌（PTC）的病理特征与高TSH水平之间的关系。
纳入2012年至2017年间接受手术且病理检查发现患有PTC的患者。评估患者中TSH与肿瘤侵袭性特征之间的关系。
在132例患者中，有血管侵犯者的TSH水平显著高于无血管侵犯者（p = 0.048），有中央区转移者高于无中央区转移者（p = 0.014），有甲状腺外扩散者高于无甲状腺外扩散者（p = 0.003）。根据TSH（mUI/mL）水平将患者分为四个25%四分位数；甲状腺外侵犯率随TSH水平升高而增加，四分位数1中的水平显著高于其他四分位数，差异有统计学意义（p = 0.030）。
术前TSH水平升高与甲状腺外扩散和中央淋巴结转移风险增加相关。TSH水平可能是术前预测患者中央转移风险的一个有价值的因素。
