Shore S A, Kariya S T, Anderson K, Skornik W, Feldman H A, Pennington J, Godleski J, Drazen J M
Am Rev Respir Dis. 1987 Apr;135(4):840-7. doi: 10.1164/arrd.1987.135.4.840.
Chronic bronchitis was induced in 7 dogs of mixed breed by chronic exposure to SO2 gas. Within the first 2 to 4 wk of exposure, the dogs developed cough and mucous hypersecretion, chronic airway obstruction (increased pulmonary resistance), and persistent lung inflammation as demonstrated by an increase in the number of neutrophils recovered in the bronchoalveolar lavage (BAL) fluid. Airway responsiveness to methacholine aerosol decreased 2- to 3-fold within 8 wk of SO2 exposure. In contrast, airway responsiveness to intravenous administration of methacholine did not change. The data suggest that the decreased airway responsiveness observed during persistent pulmonary inflammation in SO2-exposed dogs is not due to an altered state of airway contractile elements but likely reflects expression of an inhibitory influence of the mucoepithelial barrier.
通过长期暴露于二氧化硫气体，在7只杂种犬中诱发了慢性支气管炎。在暴露的最初2至4周内，这些犬出现咳嗽和黏液分泌过多、慢性气道阻塞（肺阻力增加）以及持续性肺部炎症，支气管肺泡灌洗（BAL）液中回收的中性粒细胞数量增加证明了这一点。二氧化硫暴露8周内，气道对乙酰甲胆碱气雾剂的反应性降低了2至3倍。相比之下，气道对静脉注射乙酰甲胆碱的反应性没有变化。数据表明，在暴露于二氧化硫的犬持续性肺部炎症期间观察到的气道反应性降低，不是由于气道收缩元件状态改变，而是可能反映了黏液上皮屏障抑制作用的表达。
