一种用于在活细胞中检测和成像过氧亚硝酸盐的基于萘酰亚胺的开启型荧光探针。
A naphthalimide-based turn-on fluorescence probe for peroxynitrite detection and imaging in living cells.
作者信息
Liu Xiling, Gu Fangyuan, Zhou Xinyi, Zhou Wei, Zhang Shuping, Cui Lei, Guo Ting
机构信息
College of Science, University of Shanghai for Science and Technology Shanghai 200093 China.
College of Science, Shanghai University Shanghai 200444 China.
出版信息
RSC Adv. 2020 Oct 16;10(63):38281-38286. doi: 10.1039/d0ra06564a. eCollection 2020 Oct 15.
Peroxynitrite (ONOO) is a potent biological oxidant that plays a significant role in diverse physiological and pathological processes. A novel fluorescent probe HCA-OH was developed for specific and sensitive detection of peroxynitrite, and displayed a significant fluorescence turn-on signal. With low cytotoxicity and good photostability, the probe HCA-OH could be applied in imaging ONOO distribution in HepG2 cells and live in real time. Therefore, the probe can be a promising tool for imaging .
过氧亚硝酸根（ONOO）是一种强效的生物氧化剂，在多种生理和病理过程中发挥着重要作用。开发了一种新型荧光探针HCA-OH用于特异性和灵敏地检测过氧亚硝酸根，并显示出显著的荧光开启信号。该探针HCA-OH具有低细胞毒性和良好的光稳定性，可应用于实时成像HepG2细胞中过氧亚硝酸根的分布。因此，该探针有望成为一种成像工具。
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