过氧亚硝酸盐光谱探针的最新研究进展及其在医学诊断中的潜在应用。

Beijing Key Laboratory of Environmental and Viral Oncology, Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, China.

Int J Mol Sci. 2023 Aug 15;24(16):12821. doi: 10.3390/ijms241612821.

Peroxynitrite (ONOO) is a crucial reactive oxygen species that plays a vital role in cellular signal transduction and homeostatic regulation. Determining and visualizing peroxynitrite accurately in biological systems is important for understanding its roles in physiological and pathological activity. Among the various detection methods, fluorescent probe-based spectroscopic detection offers real-time and minimally invasive detection, high sensitivity and selectivity, and easy structural and property modification. This review categorizes fluorescent probes by their fluorophore structures, highlighting their chemical structures, recognition mechanisms, and response behaviors in detail. We hope that this review could help trigger novel ideas for potential medical diagnostic applications of peroxynitrite-related molecular diseases.

过氧亚硝酸盐（ONOO）是一种重要的活性氧物质，在细胞信号转导和体内平衡调节中起着至关重要的作用。在生物系统中准确地测定和可视化过氧亚硝酸盐对于理解其在生理和病理活性中的作用非常重要。在各种检测方法中，基于荧光探针的光谱检测提供了实时和微创检测、高灵敏度和选择性以及易于结构和性质修饰。本综述按荧光探针的荧光团结构进行分类，详细介绍了它们的化学结构、识别机制和响应行为。我们希望本综述能够为潜在的与过氧亚硝酸盐相关的分子疾病的医学诊断应用提供新的思路。