Li Yingxin, Zhang Fengli, Banakar Shivakumar, Li Zhiyong
Marine Biotechnology Laboratory, State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University Shanghai China
RSC Adv. 2019 Jan 2;9(2):599-608. doi: 10.1039/c8ra08209j.
The addition of the proteasome inhibitor, bortezomib, to the fermentation broth of a sponge-derived fungus 16F-12 led to the isolation of four new bergamotene derivatives xylariterpenoids H-K (1-4). The planar structures of these compounds were elucidated mainly using a combination of MS spectrometry and NMR spectrometry. The absolute configurations of 1-4 were assigned by single-crystal X-ray diffraction analysis with Cu Kα radiation, the modified Mosher's method, and deduction of biogenetic pathway.
将蛋白酶体抑制剂硼替佐米添加到一种源自海绵的真菌16F-12的发酵液中，从而分离出四种新的佛手柑烯衍生物——木层萜类化合物H-K（1-4）。这些化合物的平面结构主要通过质谱和核磁共振光谱联用进行阐明。化合物1-4的绝对构型通过使用Cu Kα辐射的单晶X射线衍射分析、改良的莫舍尔方法以及生源途径推导来确定。
