Dalei Ganeswar, Das Subhraseema, Das Smruti Prava
Department of Chemistry, Ravenshaw University Cuttack Odisha 753003 India
RSC Adv. 2019 Jan 14;9(3):1705-1716. doi: 10.1039/c8ra09161g. eCollection 2019 Jan 9.
Smart hydrogels comprising carboxymethyl guar gum and chitosan (CMGG/CS) have been fabricated using tetraethyl orthosilicate as the crosslinker. To render the hydrogels an improved biological efficacy, non-thermal plasma assisted surface modification have been performed using Ar, O and a mixture of Ar and O gases. Enhanced surface wettability was witnessed post-plasma treatment. AFM analyses revealed the topographical changes of the hydrogels at the nano-scale level without any adverse effect on their bulk physical structure. The hydrogels exhibited pH-responsive swelling with maximum swelling in neutral pH. The release of diclofenac sodium from the hydrogels confirmed their potential towards colon-targeted drug delivery. Excellent biofilm eradication features against was demonstrated by the hydrogels. Hemolytic assay on human RBCs affirmed their hemocompatibility. Moreover, the hydrogels were found to be remarkably biodegradable. Thus, non-thermal plasma assisted surface nano-textured CMGG/CS hydrogels can be efficaciously explored for their diverse applications in biomedicine.
以正硅酸四乙酯作为交联剂制备了包含羧甲基瓜尔胶和壳聚糖的智能水凝胶（CMGG/CS）。为了提高水凝胶的生物学功效，使用氩气、氧气以及氩气和氧气的混合气体进行了非热等离子体辅助表面改性。等离子体处理后，表面润湿性增强。原子力显微镜分析揭示了水凝胶在纳米尺度上的形貌变化，且对其整体物理结构没有任何不利影响。水凝胶表现出pH响应性溶胀，在中性pH下溶胀最大。双氯芬酸钠从水凝胶中的释放证实了它们在结肠靶向给药方面的潜力。水凝胶对[此处原文缺失具体对象]表现出优异的生物膜根除特性。对人红细胞的溶血试验证实了它们的血液相容性。此外，发现水凝胶具有显著的生物可降解性。因此，非热等离子体辅助表面纳米纹理化的CMGG/CS水凝胶可有效地用于生物医学的多种应用探索。
