酒石酸三甲丙嗪治疗夜间觉醒的对照试验
Controlled trial of trimeprazine tartrate for night waking.
作者信息
Simonoff E A, Stores G
出版信息
Arch Dis Child. 1987 Mar;62(3):253-7. doi: 10.1136/adc.62.3.253.
Abstract
Mild hypnotics are often recommended for young children with sleep problems. This study assesses the efficacy of trimeprazine tartrate in 1 to 3 year old children with persistent and severe night waking in a double blind crossover trial with placebo. Children on treatment with trimeprazine had significantly fewer wakings, less time awake at night, and more night time sleep compared with those on treatment with placebo. There were no differences in these sleep variables when the first and last (fourth) week of treatment with drugs were compared. Follow up observations showed no significant difference in any sleep variables from baseline measures. The results are consistent with the idea that trimeprazine tartrate may be a useful short term treatment for night waking in young children.
摘要
轻度催眠药常被推荐用于有睡眠问题的幼儿。本研究在一项与安慰剂对照的双盲交叉试验中，评估了酒石酸三甲嗪对1至3岁持续严重夜间觉醒儿童的疗效。与接受安慰剂治疗的儿童相比，接受酒石酸三甲嗪治疗的儿童夜间觉醒次数显著减少，夜间清醒时间缩短，夜间睡眠时间增加。比较用药治疗的第一周和最后（第四）周时，这些睡眠变量没有差异。随访观察显示，与基线测量相比，任何睡眠变量均无显著差异。结果表明，酒石酸三甲嗪可能是治疗幼儿夜间觉醒的一种有效的短期治疗方法。
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