Richman N
J Child Psychol Psychiatry. 1985 Jul;26(4):591-8. doi: 10.1111/j.1469-7610.1985.tb01643.x.
A double-blind trial using trimeprazine tartrate was carried out in 22 children with severe waking problems. On parental verbal reports sleep was significantly improved on the drug compared with the original baseline and the placebo, but diaries kept by the parents showed that this improvement was clinically only moderate, with many wakeful nights still occurring. Taking the drug produced no permanent effect on sleep patterns and a follow-up of 14 children 6 months later showed persisting sleep problems in the majority.
对22名有严重清醒问题的儿童进行了一项使用酒石酸三甲丙嗪的双盲试验。根据家长的口头报告，与最初的基线和安慰剂相比，使用该药物后睡眠有显著改善，但家长记录的日记显示，这种改善在临床上仅为中度，仍有许多清醒的夜晚出现。服用该药物对睡眠模式没有产生永久性影响，6个月后对14名儿童的随访显示，大多数儿童仍存在睡眠问题。
