用于时间分辨结构生物学的α-羧基硝基苄基光笼化L-天冬氨酸盐的合成与表征
Synthesis and characterisation of α-carboxynitrobenzyl photocaged l-aspartates for applications in time-resolved structural biology.
作者信息
Zaitsev-Doyle John J, Puchert Anke, Pfeifer Yannik, Yan Hao, Yorke Briony A, Müller-Werkmeister Henrike M, Uetrecht Charlotte, Rehbein Julia, Huse Nils, Pearson Arwen R, Sans Marta
机构信息
The Hamburg Center for Ultrafast Imaging & Institute for Nanostructure and Solid State Physics Luruper Chaussee 149 22761 Hamburg Germany
Department of Physics and Centre for Hybrid Nanostructures, University of Hamburg Luruper Chaussee 149 22761 Hamburg Germany.
出版信息
RSC Adv. 2019 Mar 15;9(15):8695-8699. doi: 10.1039/c9ra00968j. eCollection 2019 Mar 12.
We report a new synthetic route to a series of α-carboxynitrobenzyl photocaged l-aspartates for application in time-resolved structural biology. The resulting compounds were characterised in terms of UV/Vis absorption properties, aqueous solubility and stability, and photocleavage rates ( = μs to ms) and quantum yields ( = 0.05 to 0.14).
我们报道了一种合成一系列α-羧基硝基苄基光笼化L-天冬氨酸盐的新路线，用于时间分辨结构生物学。对所得化合物的紫外/可见吸收特性、水溶性和稳定性、光裂解速率（=微秒至毫秒）以及量子产率（=0.05至0.14）进行了表征。
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