Ali Hassam, Pamarthy Rahul, Bolick Nicole Leigh, Lambert Karissa, Naseer Maliha
Department of Internal Medicine, East Carolina University/Vidant Medical Center, Greenville, North Carolina.
Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, Florida.
Proc (Bayl Univ Med Cent). 2022 Jan 31;35(3):278-283. doi: 10.1080/08998280.2022.2028344. eCollection 2022.
The relationship between inflammatory bowel disease (IBD) and depression is complicated. The effect of depression on ulcerative colitis (UC) and Crohn's disease (CD) among the inpatient US population has not previously been studied. We retrospectively analyzed patients admitted with UC and CD from 2016 to 2019 using the National Inpatient Sample database. Our primary outcome was the effect of depression on hospital length of stay (LOS), costs, and mortality. Secondary outcomes included the comparison between UC and CD cases. In the UC population, 13.4% had depression, compared to 14.9% in the CD population. LOS was longer in UC and CD patients with depression ( < 0.001). Subgroup analysis revealed that LOS was longer in CD patients than UC patients in the depressed cohort ( < 0.001). Inpatient hospital costs were lower in IBD patients with depression ( < 0.001). Subgroup analysis revealed that hospital cost was $17,974 higher in CD patients than UC patients ( < 0.001). Depression did not increase mortality in the IBD population but increased LOS, with a greater impact on CD than UC. White women were found to have an increased prevalence of depression in the IBD population.
炎症性肠病（IBD）与抑郁症之间的关系很复杂。此前尚未研究过抑郁症对美国住院患者中溃疡性结肠炎（UC）和克罗恩病（CD）的影响。我们使用国家住院样本数据库对2016年至2019年收治的UC和CD患者进行了回顾性分析。我们的主要结局是抑郁症对住院时间（LOS）、费用和死亡率的影响。次要结局包括UC和CD病例之间的比较。在UC患者群体中，13.4%患有抑郁症，而在CD患者群体中这一比例为14.9%。患有抑郁症的UC和CD患者住院时间更长（<0.001）。亚组分析显示，在抑郁症患者队列中，CD患者的住院时间比UC患者更长（<0.001）。患有抑郁症的IBD患者住院费用更低（<0.001）。亚组分析显示，CD患者的住院费用比UC患者高17,974美元（<0.001）。抑郁症并未增加IBD患者群体的死亡率，但增加了住院时间，对CD的影响比对UC更大。研究发现，白人女性在IBD患者群体中抑郁症患病率更高。
