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肾病患者使用治疗性大麻:加拿大肾病学家的一项调查。

Therapeutic Cannabis Use in Kidney Disease: A Survey of Canadian Nephrologists.

作者信息

Gitau Kevin, Howe Holly S, Ginsberg Lydia, Perl Jeffrey, Ailon Jonathan

机构信息

Division of General Internal Medicine, St. Michael's Hospital, Unity Health Toronto, University of Toronto, Toronto, Canada.

Department of Marketing, Fuqua School of Business, Duke University, Durham, North Carolina.

出版信息

Kidney Med. 2022 Mar 18;4(5):100453. doi: 10.1016/j.xkme.2022.100453. eCollection 2022 May.

DOI:10.1016/j.xkme.2022.100453
PMID:35518836
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9065896/
Abstract

RATIONALE & OBJECTIVE: Cannabis use may be helpful for symptom management in patients with chronic kidney disease (CKD). Knowledge, attitudes, and comfort with use of medical cannabis among kidney care providers may be limiting more widespread evaluation and use. We surveyed Canadian nephrologists regarding current prescribing habits, attitudes, and overall comfort level with cannabis products.

STUDY DESIGN

We carried out a nationwide, mail-in survey focused on capturing general and practice demographics, current cannabis prescribing status, and knowledge and attitudes regarding therapeutic cannabis use in patients with CKD.

SETTING & POPULATION: This survey was distributed to every registered nephrologist in Canada.

ANALYTICAL APPROACH

The results of this survey are reported descriptively.

RESULTS

Responses were received from 208 of 723 (29%) nephrologists. Only 21 (10.1%) respondents currently prescribe cannabis, with chronic pain syndromes being the most frequent reason for cannabis prescription (95.2%). Overall, 116 (55.5%) participants reported that changes in legality of cannabis did not influence their decision to prescribe cannabis. The majority of respondents (n = 123; 59%) indicated that they were uncomfortable with their knowledge of the medical cannabis literature. Most respondents (n=188; 91%) indicated that further studies exploring the efficacy and safety of cannabis would likely influence their prescribing habits.

LIMITATIONS

Limitations of this study include possible nonresponse bias and a lack of specific data on practice considerations for specific subpopulations, such as transplant patients.

CONCLUSIONS

Only a small minority of Canadian nephrologists currently prescribe cannabis, with relatively little practice change after legalization. There is broad support amongst Canadian nephrologists for encouraging their patients to enroll in efficacy/safety studies of cannabis in the CKD population. Ultimately, given limited therapeutic options available for symptom control in CKD, this survey demonstrates the potential for nationwide practice change if cannabis efficacy and safety can be demonstrated in this population.

摘要

原理与目的

使用大麻可能有助于慢性肾脏病(CKD)患者的症状管理。肾脏护理提供者对医用大麻的了解、态度及使用意愿可能限制了其更广泛的评估和使用。我们就当前的处方习惯、态度以及对大麻产品的总体接受程度对加拿大肾脏病学家进行了调查。

研究设计

我们开展了一项全国性的邮寄调查,重点是收集一般情况和执业人口统计学数据、当前大麻处方状况以及对CKD患者使用治疗性大麻的知识和态度。

背景与人群

该调查分发给了加拿大每一位注册肾脏病学家。

分析方法

本次调查结果采用描述性报告。

结果

723名肾脏病学家中有208名(29%)回复了问卷。目前只有2

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a03e/9065896/aba3a6ac4ced/gr5.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a03e/9065896/aba3a6ac4ced/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a03e/9065896/55d72c223b9e/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a03e/9065896/bfedbeb0c89a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a03e/9065896/60abf86eebc7/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a03e/9065896/84e4ab93b926/gr3.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a03e/9065896/aba3a6ac4ced/gr5.jpg

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本文引用的文献

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Nephrologist Views Regarding Cannabinoid Use in Advanced Chronic Kidney Disease and Dialysis: A Survey.肾病学家对晚期慢性肾脏病和透析患者使用大麻素的看法:一项调查。
J Pain Symptom Manage. 2021 Feb;61(2):237-245.e2. doi: 10.1016/j.jpainsymman.2020.08.003. Epub 2020 Aug 14.
2
Knowledge, Practices, and Attitudes of Washington State Health Care Professionals Regarding Medical Cannabis.华盛顿州医疗保健专业人员对医用大麻的知识、实践和态度
Cannabis Cannabinoid Res. 2020 Jun 5;5(2):172-182. doi: 10.1089/can.2019.0051. eCollection 2020 Jun 1.
3
The practical knowledge, experience and beliefs of US emergency medicine physicians regarding medical Cannabis: A national survey.
一项回顾性队列研究考察了大麻消费对长期肾脏结局的影响。
Cannabis Cannabinoid Res. 2024 Apr;9(2):635-645. doi: 10.1089/can.2022.0141. Epub 2023 Feb 15.
美国急诊医学医师关于医用大麻的实践知识、经验及信念:一项全国性调查。
Am J Emerg Med. 2020 Sep;38(9):1952-1954. doi: 10.1016/j.ajem.2020.01.059. Epub 2020 Jan 30.
4
Evidence of a clinically significant drug-drug interaction between cannabidiol and tacrolimus.有临床意义的药物相互作用的证据,大麻二酚和他克莫司之间。
Am J Transplant. 2019 Oct;19(10):2944-2948. doi: 10.1111/ajt.15398. Epub 2019 May 21.
5
A Review of Cannabis in Chronic Kidney Disease Symptom Management.大麻在慢性肾病症状管理中的综述
Can J Kidney Health Dis. 2019 Feb 22;6:2054358119828391. doi: 10.1177/2054358119828391. eCollection 2019.
6
Medical Marijuana-Induced Tacrolimus Toxicity.
Psychosomatics. 2019 Nov-Dec;60(6):603-605. doi: 10.1016/j.psym.2019.01.009. Epub 2019 Feb 4.
7
Oncology Clinicians and the Minnesota Medical Cannabis Program: A Survey on Medical Cannabis Practice Patterns, Barriers to Enrollment, and Educational Needs.肿瘤临床医生与明尼苏达医用大麻项目:关于医用大麻实践模式、注册障碍及教育需求的调查
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Cannabis Legalization in Canada: Reflections on Public Health and the Governance of Legal Psychoactive Substances.加拿大的大麻合法化:对公共卫生及合法精神活性物质管理的思考
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