Yao Guangkai, Wang Bing-Feng, Yang Shuai, Zhang Zhi-Xiang, Xu Han-Hong, Tang Ri-Yuan
Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, South China Agricultural University Guangzhou 510642 China
State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University Guangzhou 510642 China.
RSC Adv. 2019 Jan 25;9(6):3403-3406. doi: 10.1039/c8ra09784d. eCollection 2019 Jan 22.
DMSO was found to activate arylisothiocyanates for self-nucleophilic addition. A subsequent intramolecular C-H sulfurization catalyzed by PdBr enables access to a wide range of 2-aminobenzothiazole derivatives in moderate to good yields. This is the first example of a DMSO-mediated Pd-catalyzed synthesis of 2-aminobenzothiazoles through cyclization/C-H sulfurization of two isothiocyanates.
发现二甲基亚砜可激活芳基异硫氰酸酯以进行自亲核加成。随后由溴化钯催化的分子内C-H硫化反应能够以中等至良好的产率获得多种2-氨基苯并噻唑衍生物。这是通过两种异硫氰酸酯的环化/C-H硫化反应，由二甲基亚砜介导的钯催化合成2-氨基苯并噻唑的首个实例。
