使用dDNP超极化核磁共振实时观察6-磷酸葡萄糖异头物交换
Observation of glucose-6-phosphate anomeric exchange in real-time using dDNP hyperpolarised NMR.
作者信息
Uppala Sivaranjan, Gamliel Ayelet, Sapir Gal, Sosna Jacob, Gomori J Moshe, Katz-Brull Rachel
机构信息
Department of Radiology, Hadassah Medical Center, Hebrew University of Jerusalem, The Faculty of Medicine Jerusalem Israel
出版信息
RSC Adv. 2020 Nov 11;10(67):41197-41201. doi: 10.1039/d0ra08022e. eCollection 2020 Nov 9.
A hyperpolarised-NMR acquisition approach that is sensitive to the process of glucose-6-phosphate anomerization is presented. Using selective depolarisation of one of the anomer's signals, it is possible to observe the replenishing of this signal due to the fast anomeric exchange of this compound. The forward to reverse reaction rate constants ratio was 1.6.
本文提出了一种对6-磷酸葡萄糖异头物异构化过程敏感的超极化核磁共振采集方法。通过对其中一种异头物信号进行选择性去极化，可以观察到由于该化合物快速异头交换而导致的该信号的补充。正向与逆向反应速率常数之比为1.6。
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