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布氏蚶血蚶肌肉提取物中N-甲基-D-天冬氨酸的存在情况。

The occurrence of N-methyl-D-aspartic acid in muscle extracts of the blood shell, Scapharca broughtonii.

作者信息

Sato M, Inoue F, Kanno N, Sato Y

出版信息

Biochem J. 1987 Jan 1;241(1):309-11. doi: 10.1042/bj2410309.

DOI:10.1042/bj2410309
PMID:3551926
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1147559/
Abstract

A novel ninhydrin-positive compound, N-methyl-D-aspartic acid, was identified in the muscle extracts of the blood shell, Scapharca broughtonii. This compound is already known to have potent neuroexcitatory activity, inducing hypermotility and strong releasing action of serum luteinizing hormone in mammals. This may be, however, the first finding of N-methyl-D-aspartic acid in natural products.

摘要

在血蚶（Scapharca broughtonii）的肌肉提取物中鉴定出一种新型茚三酮阳性化合物，即N-甲基-D-天冬氨酸。已知该化合物具有强大的神经兴奋活性，可诱导哺乳动物出现活动亢进以及血清促黄体生成素的强烈释放作用。然而，这可能是在天然产物中首次发现N-甲基-D-天冬氨酸。

相似文献

1
The occurrence of N-methyl-D-aspartic acid in muscle extracts of the blood shell, Scapharca broughtonii.布氏蚶血蚶肌肉提取物中N-甲基-D-天冬氨酸的存在情况。
Biochem J. 1987 Jan 1;241(1):309-11. doi: 10.1042/bj2410309.
2
N-methyl-D-glutamate and N-methyl-L-glutamate in Scapharca broughtonii (Mollusca) and other invertebrates.
Comp Biochem Physiol B Biochem Mol Biol. 2003 Jan;134(1):79-87. doi: 10.1016/s1096-4959(02)00231-2.
3
Occurrence of free D-aspartate and aspartate racemase in the blood shell Scapharca broughtonii.
Amino Acids. 1998;14(4):353-60. doi: 10.1007/BF01318854.
4
Determination of N-methyl-D-aspartate in tissues of bivalves by high-performance liquid chromatography.高效液相色谱法测定双壳贝类组织中的N-甲基-D-天冬氨酸
J Chromatogr B Biomed Sci Appl. 1999 May 14;728(1):41-7. doi: 10.1016/s0378-4347(99)00089-4.
5
Direct activation of gonadotropin-releasing hormone secretion through different receptors to neuroexcitatory amino acids.通过不同受体对神经兴奋性氨基酸直接激活促性腺激素释放激素分泌。
Neuroendocrinology. 1989 Apr;49(4):402-8. doi: 10.1159/000125145.
6
Resolution of the neuroexcitatory N-methylaspartic acid (2-methylaminosuccinic acid) enantiomers by ligand-exchange thin-layer chromatography.通过配体交换薄层色谱法拆分神经兴奋性 N-甲基天冬氨酸（2-甲基氨基琥珀酸）对映体。
J Chromatogr. 1990 Feb 21;502(1):226-9. doi: 10.1016/s0021-9673(01)89584-4.
7
N-methyl-D,L-aspartate elicits hypothalamic gonadotropin-releasing hormone release in prepubertal male rhesus monkeys (Macaca mulatta).N-甲基-D,L-天冬氨酸可引起青春期前雄性恒河猴（猕猴）下丘脑促性腺激素释放激素的释放。
Endocrinology. 1987 Jun;120(6):2289-96. doi: 10.1210/endo-120-6-2289.
8
DL-2-amino-5-phosphonopentanoic acid, a specific N-methyl-D-aspartic acid receptor antagonist, suppresses pulsatile LH release in the rat.
Neuroendocrinology. 1988 May;47(5):465-8. doi: 10.1159/000124951.
9
Action of L-aspartic, methyl aspartic and acetyl aspartic acids on GABA transaminase histochemical activity in nervous tissue.L-天冬氨酸、甲基天冬氨酸和乙酰天冬氨酸对神经组织中γ-氨基丁酸转氨酶组织化学活性的作用。
Cell Mol Biol. 1984;30(6):553-7.
10
Effects of hypoxic and osmotic stress on the free D-aspartate level in the muscle of blood shell Scapharca broughtonii.缺氧和渗透胁迫对毛蚶肌肉中游离D-天冬氨酸水平的影响。
Amino Acids. 2005 May;28(3):291-6. doi: 10.1007/s00726-005-0188-7. Epub 2005 Mar 30.

引用本文的文献

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D-Aspartate acts as a signaling molecule in nervous and neuroendocrine systems.D-天冬氨酸在神经系统和神经内分泌系统中充当信号分子。
Amino Acids. 2012 Nov;43(5):1873-86. doi: 10.1007/s00726-012-1364-1. Epub 2012 Aug 8.
2
HPLC determination of acidic D-amino acids and their N-methyl derivatives in biological tissues.高效液相色谱法测定生物组织中的酸性D-氨基酸及其N-甲基衍生物
Biomed Chromatogr. 2009 Jun;23(6):581-7. doi: 10.1002/bmc.1156.
3
Ligands for ionotropic glutamate receptors.离子型谷氨酸受体的配体。
Prog Mol Subcell Biol. 2009;46:123-57. doi: 10.1007/978-3-540-87895-7_5.
4
N-methyl-D-aspartic acid (NMDA) in the nervous system of the amphioxus Branchiostoma lanceolatum.文昌鱼（Branchiostoma lanceolatum）神经系统中的N-甲基-D-天冬氨酸（NMDA）。
BMC Neurosci. 2007 Dec 20;8:109. doi: 10.1186/1471-2202-8-109.
5
Confirmation of D-aspartic acid in the novel dipeptide beta-aspartylglycine isolated from tissue extract of Aplysia kurodai.从日本黑兔组织提取物中分离出的新型二肽β-天冬氨酰甘氨酸中D-天冬氨酸的确认。
Biochem J. 1989 Oct 15;263(2):617-20. doi: 10.1042/bj2630617.

本文引用的文献

1
The excitation and inhibition of crustacean muscle by amino acids.氨基酸对甲壳类动物肌肉的兴奋与抑制作用。
J Physiol. 1959 Oct;148(1):39-50. doi: 10.1113/jphysiol.1959.sp006272.
2
THE EFFECT UPON MICE OF INTRAVENTRICULAR INJECTION OF EXCITANT AND DEPRESSANT AMINO ACIDS.脑室内注射兴奋性和抑制性氨基酸对小鼠的影响。
Biochem Pharmacol. 1963 Dec;12:1443-4. doi: 10.1016/0006-2952(63)90217-x.
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Effect of intraventricular injection of N-methylated GABA-derivatives on the central nervous system of conscious mice.脑室内注射N-甲基化GABA衍生物对清醒小鼠中枢神经系统的影响。
Biochem Pharmacol. 1963 Feb;12:213-4. doi: 10.1016/0006-2952(63)90186-2.
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The excitation and depression of spinal neurones by structurally related amino acids.结构相关氨基酸对脊髓神经元的兴奋和抑制作用。
J Neurochem. 1960 Sep;6:117-41. doi: 10.1111/j.1471-4159.1960.tb13458.x.
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Actions of aminoacids on the isolated hemisected spinal cord of the toad.氨基酸对蟾蜍离体半切脊髓的作用。
Br J Pharmacol Chemother. 1961 Jun;16(3):262-83. doi: 10.1111/j.1476-5381.1961.tb01086.x.
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Effects of gamma-aminobutyric acid on the isolated mammalian ileum.γ-氨基丁酸对离体哺乳动物回肠的作用。
J Physiol. 1958 Jun 18;142(1):147-64. doi: 10.1113/jphysiol.1958.sp006005.
7
The action of gamma aminobutyric acid upon cortical electrical activity in the cat.γ-氨基丁酸对猫皮层电活动的作用。
J Physiol. 1957 Oct 30;138(3):365-80. doi: 10.1113/jphysiol.1957.sp005856.
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Acute central stimulation of luteinizing hormone by parenterally administered N-methyl-D,L-aspartic acid in the male rat.
Brain Res. 1980 Feb 24;184(2):425-37. doi: 10.1016/0006-8993(80)90810-0.
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Acute motor effects of N-methyl-D-aspartic acid and kainic acid applied focally to mesencephalic dopamine cell body regions in the rat.
Neurosci Lett. 1980 May 15;18(1):85-90. doi: 10.1016/0304-3940(80)90217-7.
10
Magnesium selectively inhibits N-methyl-aspartic acid-induced hypermotility after intra-accumbens injection.伏隔核内注射后，镁选择性抑制N-甲基-D-天冬氨酸诱导的运动亢进。
Pharmacol Biochem Behav. 1984 Feb;20(2):243-6. doi: 10.1016/0091-3057(84)90249-1.